ArticleAJNR. American journal of neuroradiology2019
How Flow Reduction Influences the Intracranial Aneurysm Occlusion: A Prospective 4D Phase-Contrast MRI Study.
Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- The value of non-contrast and contrast-enhanced time-of-flight magnetic resonance angiography in the follow-up assessment of cerebral aneurysms treated with flow diverter stents.Neuroradiology · 2026Article
- Intraoperative hemispheric circulation time as a potential predictor of aneurysm occlusion after flow diverter treatment in large internal carotid artery aneurysm.Neurosurgical review · 2026Article
- Evaluating flow modulating treatment response in intracranial aneurysms using black-blood MRI in vitro.Communications medicine · 2026Article
- Near-wall hemodynamic parameters quantification in in vitro intracranial aneurysms with 7 T PC-MRI.Magma (New York, N.Y.) · 2023Article
- Accelerated dual-venc 4D flow MRI with variable high-venc spatial resolution for neurovascular applications.Magnetic resonance in medicine · 2022Article
- Influence of Spatial Resolution and Compressed SENSE Acceleration Factor on Flow Quantification with 4D Flow MRI at 3 Tesla.Tomography (Ann Arbor, Mich.) · 2022Article
- Article
- "Trapped labelled spins"-related signal on arterial spin labelling in the assessment of flow-diverted aneurysms: preliminary experience.Neuroradiology · 2022Article
- Pipeline Embolization device for intracranial aneurysms in a large Chinese cohort: factors related to aneurysm occlusion.Therapeutic advances in neurological disorders · 2020Article
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
Abstract
background and purposeFlow-diverter stents are widely used for the treatment of wide-neck intracranial aneurysms. Various parameters may influence intracranial aneurysm thrombosis, including the flow reduction induced by flow-diverter stent implantation, which is assumed to play a leading role. However, its actual impact remains unclear due to the lack of detailed intra-aneurysmal flow measurements. This study aimed to clarify this relationship by quantitatively measuring the intra-aneurysmal flow using 4D phase-contrast MR imaging. MATERIALS AND
methodsWe acquired prospective pre- and post-stent implantation 4D phase-contrast MR imaging data of a consecutive series of 23 patients treated with flow-diverter stents. Velocity field data were combined with the intraprocedural 3D angiogram vessel geometries for precise intracranial aneurysm extraction and partial volume correction. Intra-aneurysmal hemodynamic modifications were compared with occlusion outcomes at 6 and 12 months.
resultsThe averaged velocities at systole were lower after flow-diverter stent implantation for all patients and ranged from 21.7 ± 7.1 cm/s before to 7.2 ± 2.9 cm/s after stent placement. The velocity reduction was more important for the group of patients with aneurysm thrombosis at 6 months (68.8%) and decreased gradually from 66.2% to 55% for 12-month thrombosis and no thrombosis, respectively (
conclusionsWe propose an innovative approach to measure intracranial flow changes after flow-diverter stent implantation. We identified a trend between flow reduction and thrombosis outcome that brings a new insight into current understanding of the flow-diversion treatment response.
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