Evidence map›Paper›PMID 31727749›Full record

ArticleAJNR. American journal of neuroradiology2019

Validation of Highly Accelerated Wave-CAIPI SWI Compared with Conventional SWI and T2*-Weighted Gradient Recalled-Echo for Routine Clinical Brain MRI at 3T.

J Conklin, M G F Longo, S F Cauley, K Setsompop, R G González, P W Schaefer, J E Kirsch, O Rapalino, S Y Huang

Open access · hybridAbstract readComparative StudyValidation Study
In one paragraph

Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. A systematic review of ongoing clinical trials in optic pathway gliomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020
    Pooled it
  2. Accelerated 3D MRI for ARIA monitoring in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Advancements in MRI application in the morphological development of fetal cerebral venous system: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Review
  4. Ultra-fast MRI for dementia diagnosis and treatment eligibility: A prospective study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
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  7. Article
  8. Article
  9. Review
  10. Fetal MRI: what's new? A short review.European radiology experimental · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Application of Neuromelanin MR Imaging in Parkinson Disease.Journal of magnetic resonance imaging : JMRI · 2023
    Review
  15. Article
  16. Article
  17. Clinical Application of MPRAGE Wave Controlled Aliasing in Parallel Imaging (Wave-CAIPI): A Comparative Study with MPRAGE GRAPPA.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022
    Article
  18. Article
  19. Emerging Techniques and Future Directions: Fast and Portable Magnetic Resonance Imaging.Magnetic resonance imaging clinics of North America · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

J ConklinFrom the Department of Radiology (J.C., M.G.F.L., S.F.C., K.S., R.G.G., P.W.S., J.E.K., O.R., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts jconklin1@mgh.harvard.edu.ORCID 0000-0001-9921-2086
M G F LongoFrom the Department of Radiology (J.C., M.G.F.L., S.F.C., K.S., R.G.G., P.W.S., J.E.K., O.R., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0001-6819-4890
S F CauleyFrom the Department of Radiology (J.C., M.G.F.L., S.F.C., K.S., R.G.G., P.W.S., J.E.K., O.R., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0002-6147-6016
K SetsompopFrom the Department of Radiology (J.C., M.G.F.L., S.F.C., K.S., R.G.G., P.W.S., J.E.K., O.R., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0003-0455-7634
R G GonzálezFrom the Department of Radiology (J.C., M.G.F.L., S.F.C., K.S., R.G.G., P.W.S., J.E.K., O.R., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0002-0234-3897
P W SchaeferFrom the Department of Radiology (J.C., M.G.F.L., S.F.C., K.S., R.G.G., P.W.S., J.E.K., O.R., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0002-4222-6134
J E KirschFrom the Department of Radiology (J.C., M.G.F.L., S.F.C., K.S., R.G.G., P.W.S., J.E.K., O.R., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0002-0389-9475
O RapalinoFrom the Department of Radiology (J.C., M.G.F.L., S.F.C., K.S., R.G.G., P.W.S., J.E.K., O.R., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0002-5038-4183
S Y HuangFrom the Department of Radiology (J.C., M.G.F.L., S.F.C., K.S., R.G.G., P.W.S., J.E.K., O.R., S.Y.H.), Massachusetts General Hospital, Boston, Massachusetts.ORCID 0000-0003-2950-7254
Massachusetts General Hospital · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Parallel Excitation Methods for High Field MRIR01EB006847 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WALD, LAWRENCE L · 2007 to 2020
$5.4M
Noninvasive Realtime Assessment of Placental Structure and Function with Novel MR Imaging MethodsU01HD087211 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI GRANT, PATRICIA ELLEN, WALD, LAWRENCE L · 2015 to 2015
$4.9M
Rapid MRI acquisition for pediatric low-grade gliomasR01EB020613 · NIBIB · STANFORD UNIVERSITY · PI SETSOMPOP, KAWIN · 2016 to 2019
$2.5M
NCATS NIH HHS UL1 TR002541NIBIB NIH HHS P41 EB015896NIBIB NIH HHS R01 EB006847NIBIB NIH HHS R01 EB020613NICHD NIH HHS U01 HD087211
6 · The paper itself

Abstract

background and purposeSWI is valuable for characterization of intracranial hemorrhage and mineralization but has long acquisition times. We compared a highly accelerated wave-controlled aliasing in parallel imaging (CAIPI) SWI sequence with 2 commonly used alternatives, standard SWI and T2*-weighted gradient recalled-echo (T2*W GRE), for routine clinical brain imaging at 3T. MATERIALS AND

methodsA total of 246 consecutive adult patients were prospectively evaluated using a conventional SWI or T2*W GRE sequence and an optimized wave-CAIPI SWI sequence, which was 3-5 times faster than the standard sequence. Two blinded radiologists scored each sequence for the presence of hemorrhage, the number of microhemorrhages, and severity of motion artifacts. Wave-CAIPI SWI was then evaluated in head-to-head comparison with the conventional sequences for visualization of pathology, artifacts, and overall diagnostic quality. Forced-choice comparisons were used for all scores. Wave-CAIPI SWI was tested for superiority relative to T2*W GRE and for noninferiority relative to standard SWI using a 15% noninferiority margin.

resultsCompared with T2*W GRE, wave-CAIPI SWI detected hemorrhages in more cases (

conclusionsWave-CAIPI SWI provided superior visualization of pathology and overall diagnostic quality compared with T2*W GRE and was noninferior to standard SWI with reduced scan times and reduced motion artifacts.

Indexed as

AdultAgedArtifactsBrainFemaleHumansIntracranial HemorrhagesMagnetic Resonance ImagingMaleMiddle AgedNeuroimaging

Identifiers

PMID31727749
PMCPMC6911638
OpenAlexW2985565078

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.