Evidence map›Paper›PMID 31727747›Full record

ArticleAJNR. American journal of neuroradiology2019

Ultra-High-Field Targeted Imaging of Focal Cortical Dysplasia: The Intracortical Black Line Sign in Type IIb.

E Bartolini, M Cosottini, M Costagli, C Barba, L Tassi, R Spreafico, R Garbelli, L Biagi, A Buccoliero, F Giordano and 1 more

Erratum issuedAbstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Mesoscale Whole-Brain TMagnetic resonance in medicine · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

E BartoliniFrom the Department of Pediatric Neurology (E.B., C.B., A.B., R. Guerrini).ORCID 0000-0002-5683-1941
M CosottiniDepartment of Translational Research and New Technologies in Medicine and Surgery (M. Cosottini), University of Pisa, Pisa, Italy.ORCID 0000-0001-9400-6574
M CostagliIMAGO7 Research Foundation (M. Costagli), Pisa, Italy.ORCID 0000-0001-9073-1082
C BarbaFrom the Department of Pediatric Neurology (E.B., C.B., A.B., R. Guerrini).ORCID 0000-0001-5445-5842
L TassiEpilepsy Surgery Centre C. Munari (L.T.), Ospedale Niguarda, Milano, Italy.ORCID 0000-0002-0632-7296
R SpreaficoClinical Epileptology and Experimental Neurophysiology Unit (R.S., R. Garbelli), Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Neurologico C. Besta, Milano, Italy.ORCID 0000-0002-6528-1240
R GarbelliClinical Epileptology and Experimental Neurophysiology Unit (R.S., R. Garbelli), Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Neurologico C. Besta, Milano, Italy.ORCID 0000-0002-6475-4974
L BiagiIstituto Di Ricovero e Cura a Carattere Scientifico Fondazione Stella Maris (L.B., R. Guerrini), Pisa, Italy.ORCID 0000-0003-2159-439X
A BuccolieroFrom the Department of Pediatric Neurology (E.B., C.B., A.B., R. Guerrini).ORCID 0000-0002-7113-8387
F GiordanoNeurogenetics and Neurobiology Unit and Laboratories, and Pediatric Neurosurgery Unit (F.G.), Children's Hospital A. Meyer-University of Florence, Florence, Italy.ORCID 0000-0002-8415-3236
R GuerriniFrom the Department of Pediatric Neurology (E.B., C.B., A.B., R. Guerrini) r.guerrini@meyer.it.ORCID 0000-0002-7272-7079

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeConventional MR imaging has limitations in detecting focal cortical dysplasia. We assessed the added value of 7T in patients with histologically proved focal cortical dysplasia to highlight correlations between neuropathology and ultra-high-field imaging. MATERIALS AND

methodsBetween 2013 and 2019, we performed a standardized 7T MR imaging protocol in patients with drug-resistant focal epilepsy. We focused on 12 patients in whom postsurgical histopathology revealed focal cortical dysplasia and explored the diagnostic yield of preoperative 7T versus 1.5/3T MR imaging and the correlations of imaging findings with histopathology. We also assessed the relationship between epilepsy surgery outcome and the completeness of surgical removal of the MR imaging-visible structural abnormality.

resultsWe observed clear abnormalities in 10/12 patients using 7T versus 9/12 revealed by 1.5/3T MR imaging. In patients with focal cortical dysplasia I, 7T MR imaging did not disclose morphologic abnormalities (

conclusionsThe high sensitivity of 7T T2*-weighted images provides an additional tool in defining potential morphologic markers of high epileptogenicity within the dysplastic tissue of focal cortical dysplasia IIb and will likely help to more precisely plan epilepsy surgery and explain surgical failures.

Indexed as

AdolescentAdultDrug Resistant EpilepsyFemaleHumansMagnetic Resonance ImagingMaleMalformations of Cortical DevelopmentMiddle AgedNeuroimaging

Identifiers

PMID31727747
PMCPMC6975359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.