Evidence map›Paper›PMID 31727741›Full record

ArticleThe Journal of biological chemistry2019

Altered allostery of the left flipper domain underlies the weak ATP response of rat P2X5 receptors.

Liang-Fei Sun, Yan Liu, Jin Wang, Li-Dong Huang, Yang Yang, Xiao-Yang Cheng, Ying-Zhe Fan, Michael X Zhu, Hong Liang, Yun Tian and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Liang-Fei SunInstitute of Medical Sciences and Department of Pharmacology and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.ORCID 0000-0003-4059-3261
Yan LiuInstitute of Medical Sciences and Department of Pharmacology and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Jin WangInstitute of Medical Sciences and Department of Pharmacology and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Li-Dong HuangInstitute of Medical Sciences and Department of Pharmacology and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Yang YangInstitute of Medical Sciences and Department of Pharmacology and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xiao-Yang ChengInstitute of Medical Sciences and Department of Pharmacology and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Ying-Zhe FanPutuo District Center Hospital, Shanghai University of Chinese Traditional Medicine, Shanghai 200026, China.
Michael X ZhuDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas 77030.
Hong LiangState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China.
Yun TianCollege of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China.
Heng-Shan WangState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China hshwang2002@163.com.
Chang-Run GuoDepartment of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China crguocpu@126.com.
Ye YuInstitute of Medical Sciences and Department of Pharmacology and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China yuye@shsmu.edu.cn.ORCID 0000-0002-4054-8543
Shanghai Jiao Tong University · CNChina Pharmaceutical University · CNGuangxi Normal University · CNHunan Agricultural University · CNShanghai University of Traditional Chinese Medicine · CNThe University of Texas Health Science Center at Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although the extracellular ATP-gated cation channel purinergic receptor P2X5 is widely expressed in heart, skeletal muscle, and immune and nervous systems in mammals, little is known about its functions and channel-gating activities. This lack of knowledge is due to P2X5's weak ATP responses in several mammalian species, such as humans, rats, and mice. WT human P2X5 (hP2X5

Indexed as

Adenosine TriphosphateAllosteric SiteAnimalsBiotinylationCationsCross-Linking ReagentsDisulfidesExonsHEK293 CellsHumansMolecular Dynamics SimulationProtein DomainsRatsReceptors, Purinergic P2X5Recombinant Fusion ProteinsAdenosine TriphosphateCationsCross-Linking ReagentsDisulfidesReceptors, Purinergic P2X5Recombinant Fusion Proteinsallosteric regulationATP-evoked currentATP-gated ion channelconformational changegatingleft flipper domainLF domainmolecular dynamicsP2X5 receptorspurinergic receptor

Identifiers

PMID31727741
PMCPMC6926468
OpenAlexW2988495413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.