Evidence map›Paper›PMID 31727740›Full record

ArticleThe Journal of biological chemistry2019

Roseltide rT7 is a disulfide-rich, anionic, and cell-penetrating peptide that inhibits proteasomal degradation.

Antony Kam, Shining Loo, Jing-Song Fan, Siu Kwan Sze, Daiwen Yang, James P Tam

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Antony KamSchool of Biological Sciences, Nanyang Technological University, Singapore 637551.ORCID 0000-0003-2155-6887
Shining LooSchool of Biological Sciences, Nanyang Technological University, Singapore 637551.ORCID 0000-0002-2220-8297
Jing-Song FanDepartment of Biological Sciences, National University of Singapore, Singapore 117543.ORCID 0000-0002-3290-7083
Siu Kwan SzeSchool of Biological Sciences, Nanyang Technological University, Singapore 637551.ORCID 0000-0002-5652-1687
Daiwen YangDepartment of Biological Sciences, National University of Singapore, Singapore 117543.
James P TamSchool of Biological Sciences, Nanyang Technological University, Singapore 637551 JPTam@ntu.edu.sg.
Nanyang Technological University · SGNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disulfide-rich plant peptides with molecular masses of 2-6 kDa represent an expanding class of peptidyl-type natural products with diverse functions. They are structurally compact, hyperstable, and underexplored as cell-penetrating agents that inhibit intracellular functions. Here, we report the discovery of an anionic, 34-residue peptide, the disulfide-rich roseltide rT7 from

Indexed as

A549 CellsAnti-Inflammatory AgentsAntimicrobial Cationic PeptidesAntineoplastic Agents, PhytogenicCell-Penetrating PeptidesCysteineDisulfidesEndocytosisFlow CytometryHibiscusHumansMagnetic Resonance SpectroscopyMicroscopy, ConfocalMolecular ConformationPlant ExtractsPlant LectinsAnti-Inflammatory AgentsAntimicrobial Cationic PeptidesAntineoplastic Agents, PhytogenicCell-Penetrating PeptidesCysteineDisulfidesheveinPlant ExtractsPlant LectinsPlant ProteinsProteasome Endopeptidase ComplexProteasome InhibitorsUbiquitincell-penetrating peptide (CPP)cystine-knot peptidedrug actiondrug discoveryenzyme inhibitorHibiscus sabdariffanatural productpeptide chemical synthesispeptidesplant peptideprotease inhibitorproteasomeproteasome inhibitorroseltide rT7structure-function

Identifiers

PMID31727740
PMCPMC6926453
OpenAlexW2987179055

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.