Evidence map›Paper›PMID 31727736›Full record

ArticleThe Journal of biological chemistry2019

Conditional depletion of the RNA polymerase I subunit PAF53 reveals that it is essential for mitosis and enables identification of functional domains.

Rachel McNamar, Zakaria Abu-Adas, Katrina Rothblum, Bruce A Knutson, Lawrence I Rothblum

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Cryo-EM structures of human RNA polymerase I.Nature structural & molecular biology · 2021
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rachel McNamarDepartment of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma 73104.
Zakaria Abu-AdasDepartment of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma 73104.
Katrina RothblumDepartment of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma 73104.
Bruce A KnutsonDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, New York 13210.
Lawrence I RothblumDepartment of Cell Biology, University of Oklahoma College of Medicine, Oklahoma City, Oklahoma 73104 lrothblu@ouhsc.edu.
University of Oklahoma · USSUNY Upstate Medical University · US

Funding

Ribosome Biogenesis: A Molecular Checkpoint for Cardiac HypertrophyR01HL077814 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ROTHBLUM, LAWRENCE I · 2006 to 2009
$1.4M
Protein interactions and initiation by RNA polymerase IR01GM069841 · NIGMS · WEIS CENTER FOR RESEARCH-GEISINGER CLINC · PI ROTHBLUM, LAWRENCE I · 2005 to 2008
$874k
New molecular paradigms for the molecular basis and prevention of Treacher Collins syndromeR03DE027785 · NIDCR · UPSTATE MEDICAL UNIVERSITY · PI KNUTSON, BRUCE ALAN · 2018 to 2019
$162k
NHLBI NIH HHS R01 HL077814NIDCR NIH HHS R03 DE027785NIGMS NIH HHS R01 GM069841
6 · The paper itself

Abstract

Our knowledge of the mechanism of rDNA transcription has benefited from the combined application of genetic and biochemical techniques in yeast. Nomura's laboratory (Nogi, Y., Vu, L., and Nomura, M. (1991)

Indexed as

MitosisAmino Acid SequenceAnimalsCRISPR-Cas SystemsDimerizationDNA, RibosomalHelix-Turn-Helix MotifsIndoleacetic AcidsMiceProtein SubunitsRNA, Guide, CRISPR-Cas SystemsRNA Polymerase ISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsS Phase Cell Cycle CheckpointsTranscription, GeneticDNA, RibosomalIndoleacetic AcidsProtein SubunitsRNA, Guide, CRISPR-Cas SystemsRNA Polymerase ISaccharomyces cerevisiae ProteinsauxinDNA-binding proteinnucleolusribosomal ribonucleic acid (rRNA) (ribosomal RNA)RNA polymerase I

Identifiers

PMID31727736
PMCPMC6937585
OpenAlexW2982722444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.