Evidence map›Paper›PMID 31727649›Full record

ArticleBMJ open2019

Cost and cost-effectiveness of point-of-care testing and treatment for sexually transmitted and genital infections in pregnancy in low-income and middle-income countries: a systematic review protocol.

Olga Pm Saweri, Neha Batura, Rabiah Al Adawiyah, Louise Causer, Willie Pomat, Andrew Vallely, Virginia Wiseman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Frontiers in cellular and infection microbiology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Olga Pm SaweriThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia nsaweri@kirby.unsw.edu.au.ORCID 0000-0001-5142-8355
Neha BaturaInstitute for Global Health, University College London, London, UK.ORCID 0000-0002-8175-8125
Rabiah Al AdawiyahThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Louise CauserSexual Health Program, Kirby Insitute, Sydney, New South Wales, Australia.ORCID 0000-0002-8814-0678
Willie PomatInfection and Immunity, PNG Institute of Medical Research, Goroka, Papua New Guinea.
Andrew VallelyThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0003-1558-4822
Virginia WisemanSchool of Public Health and Community Medicine, The University of New South Wales, Sydney, New South Wales, Australia.

Funding

Medical Research Council MR/N006089/1
6 · The paper itself

Abstract

introductionThe economic and health burden of sexually transmitted and genital infections (henceforth, STIs) in low-income and middle-income countries (LMICs) is substantial. Left untreated, STIs during pregnancy may result in several adverse pregnancy and birth outcomes. Timely diagnosis and treatment at point-of-care (POC) can potentially improve these outcomes. Despite the availability and promotion of POC diagnostics for STIs as a key component of antenatal care in LMICs, their widespread use has been limited, owing to the high economic costs faced by individuals and health systems. To date, there have been no systematic reviews which explore the cost or cost-effectiveness of POC testing and treatment of STIs in pregnancy in LMICs. The objective of this protocol is to outline the methods that will compare, synthesise and appraise the existing literature in this domain. METHODS AND ANALYSIS: We will conduct literature searches in MEDLINE, Embase and Web of Science. To find additional literature, we will search Google Scholar and hand search reference lists of included papers. Two reviewers will independently search databases, screen titles, abstracts and full texts; when necessary a third reviewer will resolve disputes. Only cost and cost-effectiveness studies of POC testing and treatment of STIs, including syphilis, chlamydia, trichomonas, gonorrhoea and bacterial vaginosis, in pregnancy in LMICs will be included. Published checklists will be used to assess quality of reporting practices and methodological approaches. We will also assess risk of publication bias. Interstudy heterogeneity will be assessed and depending on variation between studies, a meta-analysis or narrative synthesis will be conducted. ETHICS AND DISSEMINATION: Ethical approval is not required as the review will use published literature. The results will be published in a peer-reviewed open source journal and presented at an international conference. PROSPERO REGISTRATION NUMBER: CRD42018109072.

Indexed as

Cost-Benefit AnalysisDeveloping CountriesFemaleHumansPoint-of-Care SystemsPoint-of-Care TestingPovertyPregnancyPregnancy Complications, InfectiousResearch DesignSexually Transmitted DiseasesSystematic Reviews as Topiccost-effectivenesscostsgenital infectionspoint-of-carepregnancysexually transmitted infections

Identifiers

PMID31727649
PMCPMC6887066

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.