Evidence map›Paper›PMID 31727633›Full record

ArticleG3 (Bethesda, Md.)2020

Rapid Degradation of

Michael A Q Martinez, Brian A Kinney, Taylor N Medwig-Kinney, Guinevere Ashley, James M Ragle, Londen Johnson, Joseph Aguilera, Christopher M Hammell, Jordan D Ward, David Q Matus

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 81 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Michael A Q MartinezDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0003-1178-7139
Brian A KinneyCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, and.
Taylor N Medwig-KinneyDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794.ORCID 0000-0001-7989-3291
Guinevere AshleyDepartment of Molecular, Cell, and Developmental Biology, University of California-Santa Cruz, Santa Cruz, CA 95064.
James M RagleDepartment of Molecular, Cell, and Developmental Biology, University of California-Santa Cruz, Santa Cruz, CA 95064.
Londen JohnsonDepartment of Molecular, Cell, and Developmental Biology, University of California-Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0002-8196-4957
Joseph AguileraDepartment of Molecular, Cell, and Developmental Biology, University of California-Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0003-1824-361X
Christopher M HammellCold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, and.
Jordan D WardDepartment of Molecular, Cell, and Developmental Biology, University of California-Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0001-9870-8936
David Q MatusDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, david.matus@stonybrook.edu.ORCID 0000-0002-1570-5025
University of California, Santa Cruz · USStony Brook University · USCold Spring Harbor Laboratory · US

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
Training Program in Pharmacological SciencesT32GM007518 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI GARCIA-DIAZ, MIGUEL · 1985 to 2021
$5.4M
OSCILLATORY GENE EXPRESSION AND THE MAINTENANCE OF TEMPORAL PATTERNINGR01GM117406 · NIGMS · COLD SPRING HARBOR LABORATORY · PI HAMMELL, CHRISTOPHER MARTIN · 2016 to 2025
$4.0M
Training Program in Molecular, Cell, and Developmental BiologyT32GM133391 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Needhi Bhalla · 2019 to 2026
$3.0M
Elucidating the mechanisms underlying cell cycle regulation of invasive behaviorR01GM121597 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI MATUS, DAVID · 2017 to 2021
$2.1M
Transcriptional networks controlling molting in C. elegans and B. malayiR00GM107345 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI WARD, JORDAN DAVID · 2017 to 2019
$747k
Transcriptional regulation of morphogenetic behavior and invasive cell fate specification in C. elegansF31HD100091 · NICHD · STATE UNIVERSITY NEW YORK STONY BROOK · PI KINNEY, TAYLOR · 2019 to 2021
$117k
NCI NIH HHS P30 CA045508NICHD NIH HHS F31 HD100091NIGMS NIH HHS R00 GM107345NIGMS NIH HHS R01 GM117406NIGMS NIH HHS R01 GM121597NIGMS NIH HHS T32 GM007518NIGMS NIH HHS T32 GM133391
6 · The paper itself

Abstract

As developmental biologists in the age of genome editing, we now have access to an ever-increasing array of tools to manipulate endogenous gene expression. The auxin-inducible degradation system allows for spatial and temporal control of protein degradation via a hormone-inducible

Indexed as

ProteolysisAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsIndoleacetic AcidsLarvaMicrofluidicsNaphthaleneacetic AcidsSingle-Cell AnalysisUbiquitin-Protein Ligases1-naphthaleneacetic acidCaenorhabditis elegans ProteinsIndoleacetic AcidsNaphthaleneacetic AcidsUbiquitin-Protein LigasesAID systemC. elegansmicrofluidicsNHR-25SCF complexsynthetic auxin

Identifiers

PMID31727633
PMCPMC6945041
OpenAlexW2988057850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.