Evidence map›Paper›PMID 31727378›Full record

ArticleUltrasound in medicine & biology2020

Shear Wave Elastography Can Differentiate between Radiation-Responsive and Non-responsive Pancreatic Tumors: An ex Vivo Study with Murine Models.

Hexuan Wang, Bradley Mills, Reem Mislati, Rifat Ahmed, Scott A Gerber, David Linehan, Marvin M Doyley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hexuan WangDepartment of Electrical & Computer Engineering, University of Rochester, Rochester, New York, USA.
Bradley MillsDepartment of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
Reem MislatiDepartment of Electrical & Computer Engineering, University of Rochester, Rochester, New York, USA.
Rifat AhmedDepartment of Electrical & Computer Engineering, University of Rochester, Rochester, New York, USA.
Scott A GerberDepartment of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
David LinehanDepartment of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
Marvin M DoyleyDepartment of Electrical & Computer Engineering, University of Rochester, Rochester, New York, USA. Electronic address: m.doyley@rochester.edu.
University of Rochester · USUniversity of Rochester Medical Center · US

Funding

Development of a New Strategy to Treat Locally Advanced Pancreatic CancerR01CA230277 · NCI · UNIVERSITY OF ROCHESTER · PI GERBER, SCOTT ANDREW · 2019 to 2023
$2.0M
Surrogate imaging biomarkers for tracking anti-stromal therapyR56EB024320 · NIBIB · UNIVERSITY OF ROCHESTER · PI DOYLEY, MARVIN M · 2017 to 2017
$440k
NCI NIH HHS R01 CA230277NIBIB NIH HHS R56 EB024320
6 · The paper itself

Abstract

Neither contrast-enhanced computed tomography nor magnetic resonance imaging can monitor changes in the pancreatic ductal adenocarcinoma microenvironment during therapy. We hypothesized that shear wave elastography could overcome this limitation. To test this hypothesis, we measured the shear modulus of two groups of murine pancreatic tumors (KCKO, n = 30; PAN02, n = 30) treated with stereotactic body radiation therapy (SBRT). The mean shear modulus of KCKO tumors was 7.651 kPa higher than that of PAN02 tumors (p < 0.001). SBRT reduced the shear modulus in KCKO tumors by 8.914 kPa (p < 0.001). No significant difference in the shear modulus of SBRT-treated PAN02 tumors was observed. Additionally, necrotic and collagen densities were reduced only in the SBRT-treated KCKO tumors. Shear modulus was dependent on collagen distribution and histological texture parameters (i.e., entropy and fractional dimension). Shear wave elastography imaging differentiates between SBRT-responsive (KCKO) and non-responsive (PAN02) tumors.

Indexed as

Elasticity Imaging TechniquesAnimalsCarcinoma, Pancreatic DuctalDiagnosis, DifferentialDisease Models, AnimalFemaleMiceMice, Inbred C57BLPancreatic NeoplasmsTreatment OutcomePancreatic ductal adenocarcinomaShear modulusStereotactic body radiation therapyTumor microenvironment

Identifiers

PMID31727378
PMCPMC7060930
OpenAlexW2985859432

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.