ArticleBreast cancer research : BCR2019
Pubertal timing and breast density in young women: a prospective cohort study.
Article in Breast cancer research : BCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Consumption of ultraprocessed foods and breast density in adolescence.Scientific reports · 2025Article
- Early thelarche, reproductive hormones, and MRI-based breast density: a prospective study in China.Breast cancer research : BCR · 2025Article
- Lifecourse Growth and Development Determinants of Mammographic Density in Black Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Association between breastfeeding, mammographic density, and breast cancer risk: a review.International breastfeeding journal · 2024Review
- PFAS Levels, Early Life Factors, and Mammographic Breast Density in Premenopausal Women.Environmental health perspectives · 2024Article
- The Prospective Association between Early Life Growth and Breast Density in Young Adult Women.Cancers · 2024Article
- The Associations between Intakes of One-Carbon Metabolism-Related Vitamins and Breast Density among Young Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Breast composition during and after puberty: the Chilean Growth and Obesity Cohort Study.Breast cancer research : BCR · 2024Article
- Age at menarche and risk of ovarian hyperstimulation syndrome in women undergoing IVF/ICSI cycles: a retrospective cohort study.BMJ open · 2024Article
- Variability in urinary phthalates, phenols, and parabens across childhood and relation to adolescent breast composition in Chilean girls.Environment international · 2022Article
- Deep Learning Image Analysis of Benign Breast Disease to Identify Subsequent Risk of Breast Cancer.JNCI cancer spectrum · 2021Article
- Pubertal timing and breast cancer risk in the Sister Study cohort.Breast cancer research : BCR · 2020Article
- Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche.Breast cancer research : BCR · 2020Article
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12 authors.
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Abstract
backgroundEarlier age at onset of pubertal events and longer intervals between them (tempo) have been associated with increased breast cancer risk. It is unknown whether the timing and tempo of puberty are associated with adult breast density, which could mediate the increased risk.
methodsFrom 1988 to 1997, girls participating in the Dietary Intervention Study in Children (DISC) were clinically assessed annually between ages 8 and 17 years for Tanner stages of breast development (thelarche) and pubic hair (pubarche), and onset of menses (menarche) was self-reported. In 2006-2008, 182 participants then aged 25-29 years had their percent dense breast volume (%DBV) measured by magnetic resonance imaging. Multivariable, linear mixed-effects regression models adjusted for reproductive factors, demographics, and body size were used to evaluate associations of age and tempo of puberty events with %DBV.
resultsThe mean (standard deviation) and range of %DBV were 27.6 (20.5) and 0.2-86.1. Age at thelarche was negatively associated with %DBV (p trend = 0.04), while pubertal tempo between thelarche and menarche was positively associated with %DBV (p trend = 0.007). %DBV was 40% higher in women whose thelarche-to-menarche tempo was 2.9 years or longer (geometric mean (95%CI) = 21.8% (18.2-26.2%)) compared to women whose thelarche-to-menarche tempo was less than 1.6 years (geometric mean (95%CI) = 15.6% (13.9-17.5%)).
conclusionsOur results suggest that a slower pubertal tempo, i.e., greater number of months between thelarche and menarche, is associated with higher percent breast density in young women. Future research should examine whether breast density mediates the association between slower tempo and increased breast cancer risk.
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