Evidence map›Paper›PMID 31727044›Full record

ArticleBMC medical ethics2019

Compensation of subjects for participation in biomedical research in resource - limited settings: a discussion of practices in Malawi.

Wongani Nyangulu, Randy Mungwira, Nginanche Nampota, Osward Nyirenda, Lufina Tsirizani, Edson Mwinjiwa, Titus Divala

Abstract read
In one paragraph

Article in BMC medical ethics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  6. Review
  7. Ethics and regulatory complexities posed by a pragmatic clinical trial: a case study from Lilongwe, Malawi.Malawi medical journal : the journal of Medical Association of Malawi · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wongani NyanguluPublic Health Nutrition Research Group (PHNG), College of Medicine, Blantyre, Malawi. wnyangulu@gmail.com.ORCID 0000-0001-6192-6534
Randy MungwiraBlantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi.
Nginanche NampotaBlantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi.
Osward NyirendaBlantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi.
Lufina TsirizaniMalawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Edson MwinjiwaDignitas International, Zomba, Malawi.
Titus DivalaHelse Nord Tuberculosis Initiative, University of Malawi College of Medicine, Blantyre, Malawi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCompensating participants of biomedical research is a common practice. However, its proximity with ethical concerns of coercion, undue influence, and exploitation, demand that participant compensation be regulated. The objective of this paper is to discuss the current regulations for compensation of research participants in Malawi and how they can be improved in relation to ethical concerns of coercion, undue influence, and exploitation. MAIN TEXT: In Malawi, national regulations recommend that research subjects be compensated with a stipend of US$10 per study visit. However, no guidance is provided on how this figure was determined and how it should be implemented. While necessary to prevent exploitation, the stipend may expose the very poor to undue influence. The stipend may also raise the cost of doing research disadvantaging local researchers and may have implications on studies where income stipend is the intervention under investigation. We recommend that development and implementation of guidelines of this importance involve interested parties such as the research community and patient groups.

conclusionCompensating human research subjects is important but can also act as a barrier to voluntary participation and good research efforts. Deliberate measures need to be put in place to ensure fair compensation of research participants, avoid their exploitation and level the field for locally funded research.

Indexed as

Developing CountriesIncomeResearch SubjectsBiomedical ResearchCoercionGuidelines as TopicHumansMalawiBiomedical researchCoercionCompensationExploitationResearch participantUndue influence

Identifiers

PMID31727044
PMCPMC6857211

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.