Evidence map›Paper›PMID 31726870›Full record

ArticleDiabetes & vascular disease research

Ablation of angiotensin type 2 receptor prevents endothelial nitric oxide synthase glutathionylation and nitration in ischaemic abductor muscle of diabetic mice.

Stéphanie Robillard, Clément Mercier, Valérie Breton, Judith Paquin-Veillette, Andréanne Guay, Farah Lizotte, Pedro Geraldes

Open access · hybridAbstract read
In one paragraph

Article in Diabetes & vascular disease research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stéphanie RobillardResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada.
Clément MercierResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada.
Valérie BretonResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada.
Judith Paquin-VeilletteResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada.
Andréanne GuayResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada.
Farah LizotteResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada.
Pedro GeraldesResearch Center of the Centre Hospitalier Universitaire de Sherbrooke, Québec, Canada.ORCID 0000-0002-2613-6710
Centre Hospitalier Universitaire de Sherbrooke · CAUniversité de Sherbrooke · CA

Funding

CIHR PTJ159627
6 · The paper itself

Abstract

Peripheral artery disease is a severe complication of diabetes. We have reported that the deletion of angiotensin type 2 receptor in diabetic mice promoted vascular angiogenesis in the ischaemic muscle 4 weeks following ischaemia. However, the angiotensin type 2 receptor deletion beneficial effects occurred 2 weeks post surgery suggesting that angiotensin type 2 receptor may regulate other pro-angiogenic signalling pathways during the early phases of ischaemia. Nondiabetic and diabetic angiotensin type 2 receptor-deficient mice (

Indexed as

Neovascularization, PhysiologicAnimalsApoptosisBlood Flow VelocityCattleCells, CulturedDiabetes MellitusDisease Models, AnimalEndothelial CellsGlutathioneHindlimbIschemiaMice, Inbred C57BLMice, KnockoutMuscle, SkeletalNitratesAgtr2 protein, mouseGlutathioneNitratesNitric Oxide Synthase Type IIINos3 protein, mouseReceptor, Angiotensin, Type 2Angiotensin type 2 receptordiabetesendothelial nitric oxide synthaseperipheral arterial diseasevascular endothelial growth factor

Identifiers

PMID31726870
PMCPMC7510371
OpenAlexW2984165045

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.