Evidence map›Paper›PMID 31726801›Full record

SynthesisBiomolecules2019

Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives.

Aleksandra Maria Juszczak, Marijana Zovko-Končić, Michał Tomczyk

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Biomolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Pioneering study of Egyptian Neem and Jojoba extracts with molecular docking combat hospital multidrug resistant bacteria.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  3. Article
  4. Therapeutic Expedition of Luteolin against Brain-related Disorders: An Updated Review.Combinatorial chemistry & high throughput screening · 2025
    Review
  5. Article
  6. A Relook into the Flavonoid Chemical Space ofJournal of analytical methods in chemistry · 2023
    Article
  7. Chromatographic analysis of selected phytosterols fromCurrent research in toxicology · 2023
    Article
  8. Article
  9. Article
  10. Densitometric Quantification and Optimization of Polyphenols inSaudi journal of biological sciences · 2022
    Article
  11. Network Pharmacology- and Molecular Docking-Based Identification of Potential Phytocompounds fromEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  12. Zapotin, a Polymethoxyflavone, with Potential Therapeutic Attributes.International journal of molecular sciences · 2021
    Review
  13. Sanguiins-Promising Molecules with Broad Biological Potential.International journal of molecular sciences · 2021
    Review
  14. Review
  15. In Vitro Anticancer Potential ofInternational journal of molecular sciences · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. [Luteolin reverses OPCML methylation to inhibit proliferation of breast cancer MDA-MB-231 cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Aleksandra Maria JuszczakDepartment of Pharmacognosy, Faculty of Pharmacy, Medical University of Białystok, ul. Mickiewicza 2a, 15-230 Białystok, Poland.
Marijana Zovko-KončićDepartment of Pharmacognosy, University of Zagreb, Faculty of Pharmacy and Biochemistry, A. Kovačića 1, 10000 Zagreb, Croatia.
Michał TomczykDepartment of Pharmacognosy, Faculty of Pharmacy, Medical University of Białystok, ul. Mickiewicza 2a, 15-230 Białystok, Poland.
Medical University of Białystok · PLUniversity of Zagreb · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Luteolin is a flavonoid often found in various medicinal plants that exhibits multiple biological effects such as antioxidant, anti-inflammatory and immunomodulatory activity. Commercially available medicinal plants and their preparations containing luteolin are often used in the treatment of hypertension, inflammatory diseases, and even cancer. However, to establish the quality of such preparations, appropriate analytical methods should be used. Therefore, the present paper provides the first comprehensive review of the current analytical methods that were developed and validated for the quantitative determination of luteolin and its C- and O-derivatives including orientin, isoorientin, luteolin 7-O-glucoside and others. It provides a systematic overview of chromatographic analytical techniques including thin layer chromatography (TLC), high performance thin layer chromatography (HPTLC), liquid chromatography (LC), high performance liquid chromatography (HPLC), gas chromatography (GC) and counter-current chromatography (CCC), as well as the conditions used in the determination of luteolin and its derivatives in plant material.

Indexed as

Chromatography, High Pressure LiquidChromatography, Thin LayerFlavonesFlavonoidsGlucosidesLuteolinFlavonesFlavonoidsGlucosideshomoorientinLuteolinluteolin-7-glucosideorientinchromatographyhyphenated techniquesluteolin

Identifiers

PMID31726801
PMCPMC6921003
OpenAlexW2987732997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.