Evidence map›Paper›PMID 31726691›Full record

ArticleInternational journal of molecular sciences2019

Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer.

Vincenzo Carafa, Angelita Poziello, Laura Della Torre, Pia Giovannelli, Marzia Di Donato, Elham Safadeh, Zhijun Yu, Alfonso Baldi, Gabriella Castoria, Daniela Tomaselli and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Benzodeazaoxaflavin Sirtuin Inhibitors InhibitACS infectious diseases · 2025
    Article
  2. Review
  3. Review
  4. Review
  5. ArylamineFrontiers in pharmacology · 2022
    Article
  6. Article
  7. The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Vincenzo CarafaDipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Napoli, Italy.ORCID 0000-0002-8025-3758
Angelita PozielloDipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
Laura Della TorreDipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
Pia GiovannelliDipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Napoli, Italy.ORCID 0000-0002-2488-917X
Marzia Di DonatoDipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Napoli, Italy.ORCID 0000-0001-7207-826X
Elham SafadehDipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
Zhijun YuDipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
Alfonso BaldiDipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche Università degli Studi della Campania "Luigi Vanvitelli", 81100 Caserta, Italy.
Gabriella CastoriaDipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Napoli, Italy.ORCID 0000-0002-0576-4494
Daniela TomaselliDipartimento di Chimica e Tecnologie del Farmaco "Sapienza" Università di Roma, 00185 Roma, Italy.
Antonello MaiDipartimento di Chimica e Tecnologie del Farmaco "Sapienza" Università di Roma, 00185 Roma, Italy.ORCID 0000-0001-9176-2382
Dante RotiliDipartimento di Chimica e Tecnologie del Farmaco "Sapienza" Università di Roma, 00185 Roma, Italy.ORCID 0000-0002-8428-8763
Angela NebbiosoDipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Napoli, Italy.
Lucia AltucciDipartimento di Medicina di Precisione, Università degli Studi della Campania "Luigi Vanvitelli", 80138 Napoli, Italy.ORCID 0000-0002-7312-5387
University of Campania "Luigi Vanvitelli" · ITSapienza University of Rome · IT

Funding

AIRC 19162AIRC- 17217Campania Regional Government FASE 2: IDEAL CUP B63D18000560007Campania Regional Government Lotta alle Patologie Oncologiche, iCURE CUP B21c17000030007EU- FP7-BLUEPRINT (282510) 282510Italian Ministry of Health GR-2018-12366268Ministero della Salute PE-2013-02355271MIUR PRIN-20152TE5PKUniversità degli Studi della Campania "L.Vanvitelli" VALERE: Vanvitelli per la Ricerca Program
6 · The paper itself

Abstract

Sirtuins, a family of nicotinamide adenine dinucleotide (NAD

Indexed as

Antineoplastic AgentsHistone Deacetylase InhibitorsNeoplasm ProteinsNeoplasmsSirtuin 1Sirtuin 2AnimalsHL-60 CellsHumansK562 CellsMiceMice, Inbred BALB CMice, NudeMolybdoferredoxinU937 CellsAntineoplastic AgentsHistone Deacetylase InhibitorsMolybdoferredoxinNeoplasm ProteinsSIRT1 protein, humanSIRT2 protein, humanSirtuin 1Sirtuin 2cancercell cyclemigrationsirtuins

Identifiers

PMID31726691
PMCPMC6888689
OpenAlexW2986707640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.