ArticleInternational journal of molecular sciences2019
Defect of Interferon γ Leads to Impaired Wound Healing through Prolonged Neutrophilic Inflammatory Response and Enhanced MMP-2 Activation.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 66 citations in OpenAlex.
- Postnatal outcomes of in utero repair of simple gastroschisis in an ovine model.Journal of pediatric surgery · 2026Article
- A transparent osmotic wound dressing ATKPAD promotes the healing process and regulates hypoxia-dependent inflammatory responses.Scientific reports · 2026Article
- Integrating platelet-rich plasma therapy into nursing practice: a review of biological mechanisms and clinical applications.Frontiers in bioengineering and biotechnology · 2026Review
- GM-CSF ameliorates inflammation from Pseudomonas aeruginosa in a juvenile mouse model of burn injury.Journal of leukocyte biology · 2025Article
- Mechanical Processing of Lipoaspirate With a Fluidic Device Platform Promotes Wound Healing Transcriptional Programs and Angiogenesis In Vitro.Aesthetic surgery journal · 2025Article
- Regional heterogeneity in vascular contractile dysfunction in diabetic mice.Molecular and cellular biochemistry · 2025Article
- Imbalance of T cell subsets: a core event that mediates the progression of T2DM and its complications.Frontiers in immunology · 2025Review
- Collagen-Heparin-FGF2-VEGF Scaffolds Induce a Regenerative Gene Expression Profile in a Fetal Sheep Wound Model.Tissue engineering and regenerative medicine · 2024Article
- Epithelial RANKL Limits Experimental Periodontitis via Langerhans Cells.Journal of dental research · 2024Article
- Impact of Epigenetics, Diet, and Nutrition-Related Pathologies on Wound Healing.International journal of molecular sciences · 2024Review
- Article
- Development and functional testing of a novel in vitro delayed scratch closure assay.Histochemistry and cell biology · 2024Article
- Spatiotemporal orchestration of macrophage activation trajectories by Vγ4 T cells during skin wound healing.iScience · 2024Article
- The response of salivary proinflammatory biomarkers to tooth extraction in individuals with type II diabetes mellitus.BMC oral health · 2024Article
- Exosomes isolated from IMMUNEPOTENT CRP, a hemoderivative, to accelerate diabetic wound healing.Frontiers in bioengineering and biotechnology · 2024Article
- Article
- Comparison of Leukocyte-Rich and Leukocyte-Poor Platelet-Rich Plasma on Pressure Ulcer in a Rat Model.Journal of burn care & research : official publication of the American Burn Association · 2023Article
- Wound Healing Effect of Supercritical Carbon DioxidePlants (Basel, Switzerland) · 2023Article
- Effects of glutamine and arginine combination on pro- and anti-inflammatory cytokines.Open veterinary journal · 2023Article
- Network analyses reveal new insights into the effect of multicomponent Tr14 compared to single-component diclofenac in an acute inflammation model.Journal of inflammation (London, England) · 2023Article
Corrections and comments
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Authors and funding
21 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interferon (IFN)-γ is mainly secreted by CD4+ T helper 1 (Th1), natural killer (NK) and NKT cells after skin injury. Although IFN-γ is well known regarding its inhibitory effects on collagen synthesis by fibroblasts in vitro, information is limited regarding its role in wound healing in vivo. In the present study, we analyzed how the defect of IFN-γ affects wound healing. Full-thickness wounds were created on the backs of wild type (WT) C57BL/6 and IFN-γ-deficient (KO) mice. We analyzed the percent wound closure, wound breaking strength, accumulation of leukocytes, and expression levels of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.