Evidence map›Paper›PMID 31726429›Full record

ArticleDrug and alcohol dependence2019

Identifying subtypes of cannabis users based on simultaneous polysubstance use.

Christal N Davis, Wendy S Slutske, Nicholas G Martin, Arpana Agrawal, Michael T Lynskey

Registry-linked trialOpen access · greenAbstract readTwin Study
In one paragraph

Article in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04627922 (N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04627922 phase4completednot on this mapstarted 2021, after this paper: background citation

N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use: A Randomized Controlled Trial

TypeinterventionalSponsorEllen HerbstRan2021 to 2025Enrolled41ConditionsCannabis Use, Tobacco Use Disorder, Drug Use DisorderArmsN-Acetyl cysteine, Placebo comparator, Cognitive behavioral therapy (CBT)
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

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  7. Differentiating people who use cannabis heavily through latent class analysis.Substance abuse treatment, prevention, and policy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Christal N DavisUniversity of Missouri, Department of Psychological Sciences, Columbia, MO, 65211, USA. Electronic address: cd485@mail.missouri.edu.
Wendy S SlutskeUniversity of Missouri, Department of Psychological Sciences, Columbia, MO, 65211, USA.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
Arpana AgrawalWashington University School of Medicine, St. Louis, MO, 63110, USA.
Michael T LynskeyKing's College London Institute of Psychiatry, Psychology, & Neuroscience, London, SE5 8BB, UK.
University of Missouri · USKing's College London · GBQIMR Berghofer Medical Research Institute · AUWashington University in St. Louis · US

Funding

Psychology of Alcohol Use and Dependence TrainingT32AA013526 · NIAAA · UNIVERSITY OF MISSOURI-COLUMBIA · PI DENIS M MCCARTHY, KENNETH JAMES SHER · 2002 to 2026
$9.0M
Cannabis and Other Illicit Drug Use: A Twin StudyR01DA018267 · NIDA · WASHINGTON UNIVERSITY · PI LYNSKEY, MICHAEL THOMAS · 2005 to 2009
$2.4M
DELINEATING THE ROLE OF GENETIC INFLUENCES ON CANNABIS INVOLVEMENTK02DA032573 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA · 2012 to 2021
$1.1M
NIAAA NIH HHS T32 AA013526NIDA NIH HHS K02 DA032573NIDA NIH HHS R01 DA018267
6 · The paper itself

Abstract

backgroundCannabis use patterns vary considerably, with many users reporting simultaneous and non-simultaneous use (co-use) of other substances. Despite this, little research has examined the extent to which subtypes of cannabis users may be identified based on their simultaneous and co-use behaviors.

methodsThe sample consisted of adult Australian twins and siblings who reported lifetime cannabis use (n = 2590). A latent class analysis was conducted to determine subtypes of cannabis users based on five indicators of substance co-use and simultaneous use. Adolescent correlates (age of substance initiation and conduct disorder) and adult correlates (substance use/disorder and depression) of class membership were assessed. Twin similarity for class membership was also examined.

resultsFour subtypes of users were identified: 1) alcohol co-users, 2) simultaneous alcohol users, 3) simultaneous tobacco users, and 4) simultaneous alcohol, tobacco, and drug users. Compared to co-users of alcohol, simultaneous alcohol users were at increased risk for alcohol problems. Patterns of use that involved simultaneous tobacco and cannabis use (i.e., simultaneous tobacco users and simultaneous alcohol, tobacco, and drug users) were associated with the most problematic outcomes, including substance use and disorder. There was evidence for genetic influences (12-58%) on cannabis use patterns, with higher concordance for latent class membership among monozygotic compared to dizygotic twins (χ

conclusionsThe current study identified four classes of cannabis users at varying degrees of risk. Results suggest that simultaneous tobacco and cannabis use may be especially associated with deleterious outcomes.

Indexed as

AdolescentAdultAlcohol DrinkingAustraliaCohort StudiesDrug UsersFemaleHumansMaleMarijuana SmokingRegistriesSubstance-Related DisordersTwins, DizygoticTwins, MonozygoticYoung AdultCannabisCo-useLatent class analysisSimultaneous polysubstance use

Identifiers

PMID31726429
PMCPMC6893147
OpenAlexW2982400985

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.