ArticlePloS one2019
In vitro modeling of Batrachochytrium dendrobatidis infection of the amphibian skin.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Using fluorescent in vitro amphibian cell infection models to quantify pathogenicity of Batrachochytrium dendrobatidis.Methods (San Diego, Calif.) · 2026Article
- Glutathione Impacts Both Batrachochytrium dendrobatidis Virulence and Amphibian Cellular Defense in a Chytridiomycosis Model.MicrobiologyOpen · 2026Article
- Infectivity of amphibian chytrid fungi requires metalloprotease-driven spore development and germ tube formation.BMC microbiology · 2026Article
- Glutathione impacts bothbioRxiv : the preprint server for biology · 2026Article
- Identification of Opportunistic Pathogens on the Skin of Salamanders for Use as Molecular Targets of a De Novo Design of Multitarget Anti-International journal of microbiology · 2026Article
- In Vitro Infection Model Using A6 Cells Sets the Stage for Host-Journal of fungi (Basel, Switzerland) · 2025Article
- High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic.PLoS pathogens · 2024Article
- Stable in vitro fluorescence for enhanced live imaging of infection models for Batrachochytrium dendrobatidis.PloS one · 2024Article
- Lymphocyte Inhibition by the Salamander-Killing Chytrid Fungus, Batrachochytrium salamandrivorans.Infection and immunity · 2022Article
- Presence of low virulence chytrid fungi could protect European amphibians from more deadly strains.Nature communications · 2020Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The largest current disease-induced loss of vertebrate biodiversity is due to chytridiomycosis and despite the increasing understanding of the pathogenesis, knowledge unravelling the early host-pathogen interactions remains limited. Batrachochytrium dendrobatidis (Bd) zoospores attach to and invade the amphibian epidermis, with subsequent invasive growth in the host skin. Availability of an in vitro assay would facilitate in depth study of this interaction while reducing the number of experimental animals needed. We describe a fluorescent cell-based in vitro infection model that reproduces host-Bd interactions. Using primary keratinocytes from Litoria caerulea and the epithelial cell line A6 from Xenopus laevis, we reproduced different stages of host cell infection and intracellular growth of Bd, resulting in host cell death, a key event in chytridiomycosis. The presented in vitro models may facilitate future mechanistic studies of host susceptibility and pathogen virulence.
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