Observational studyPloS one2019
EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America.
Observational study in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Probiotics in septic acute kidney injury, a double blind, randomized control trial.Renal failure · 2023Trial
- Infection-associated acute kidney injury in resource-limited settings.Nature reviews. Nephrology · 2026Review
- LATAM-AKID registry: an international multicentre, observational study of acute kidney injury requiring dialysis in Latin America.BMJ open · 2026Observational
- Global incidence of acute kidney injury and renal replacement therapy among obstetric intensive care unit admissions: a systematic review and meta-analysis.Journal of anesthesia, analgesia and critical care · 2026Article
- Global Perspective on Acute Kidney Injury in Chile.Kidney360 · 2025Article
- Acute kidney injury and chronic kidney disease in Chile: Temporal trends in hospitalization rates from 2010 to 2019.PloS one · 2025Article
- Observational
- Article
- Pregnancy-Associated Acute Kidney Injury in Low-Resource Settings: Progress Over the Last Decade.Seminars in nephrology · 2022Review
- Observational
- Article
- Outcomes of critically ill patients with acute kidney injury in COVID-19 infection: an observational study.Renal failure · 2021Observational
- Acute kidney injury requiring renal replacement therapy during the COVID-19 pandemic: what are our options for treating it in Latin America?Kidney international · 2021Article
- Article
- Waiting List and Kidney Transplant Vascular Risk: An Ongoing Unmet Concern.Kidney & blood pressure research · 2020Review
- Renal Replacement Therapy for Acute Kidney Injury in COVID-19 Patients in Latin America.Kidney & blood pressure research · 2020Article
- Article
- Acute kidney disease in patients with COVID-19. A prospective, multicenter, multinational study in Latin America.Jornal brasileiro de nefrologiaObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEpidemiology of acute kidney injury (AKI) is highly dependent on patient characteristics, context and geography. Considering the limited information in Latin America and the Caribbean, we performed a study with the aim to contribute to improve its better understanding.
methodsObservational, prospective, longitudinal, multinational cohort study addressed to determine risk factors, clinical profile, process of care and outcomes of AKI in the region. Patients meeting KDIGO AKI definition were included over a 9-month period and designated community or hospital-acquired. De-identified clinical and lab data were entered in a specifically designed on-line platform. Co-variables potentially linked to AKI onset, in-hospital and 90-days mortality, were recorded and correlated using a multiple logistic regression model.
resultsFifty-seven physicians from 15 countries provided data on 905 patients, most with acceptable basic needs coverage. Median age 64 (50-74) yrs; most of them were male (61%) and mestizos (42%). Comorbidities were present in 77%. AKI was community-acquired in 62%. Dehydration, shock and nephrotoxic drugs were the commonest causes. During their process of care, 77% of patients were assessed by nephrologists. Kidney replacement therapy (KRT) was performed in 29% of cases. In-hospital mortality was 26.5% and independently associated to older age, chronic liver disease, hypotension, shock, cardiac disturbances, hospital-acquired sepsis, KRT and mechanical ventilation. At 90-days follow up partial or complete renal recovery was 81% and mortality 24%.
conclusionsAKI was mainly community-acquired, in patients with comorbidities and linked to fluid loss and nephrotoxic drugs. Mortality was high and long-term follow up poor. Notwithstanding, the study shows partially the situation in the participant countries rather than the actual epidemiology of AKI in Latin America and Caribbean, a pending and needed task.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.