Evidence map›Paper›PMID 31725420›Full record

ReviewCurrent opinion in psychiatry2020

Recent neuro-imaging findings with respect to conduct disorder, callous-unemotional traits and psychopathy.

Robert James R Blair, Ru Zhang

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Observational
  6. Article
  7. Article
  8. Classifying Conduct Disorder Using a Biopsychosocial Model and Machine Learning Method.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Robert James R BlairCenter for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, Nebraska, USA.
Ru Zhang
Boys Town · USBoys Town National Research Hospital · US

Funding

Acute threat and frustrative non-reward components of irritability and reactive aggressionK22MH109558 · NIMH · FATHER FLANAGAN'S BOYS' HOME · PI BLAIR, JAMES · 2016 to 2018
$972k
NIMH NIH HHS K22 MH109558
6 · The paper itself

Abstract

purpose of reviewTo review recent neuro-imaging findings with respect to conduct disorder and callous-unemotional traits in childhood and comparable psychopathy in adult-hood that deepen the literature in important ways. RECENT

findingsRecent structural findings particularly bring clarity to the literature. First, they reinforce previous work indicating that severity of psychopathy is positively associated with extent of cavum septum pellucidum. This suggests psychopathy is associated with early neurodevelopmental disruption within limbic structures. Second, they clarify the direction of the association between conduct disorder and particularly callous-unemotional traits and white matter tract abnormalities even if it remains less transparent exactly which tracts are disrupted. However, conclusions based on recent functional imaging studies are more equivocal with inconsistencies in direction of emotional (albeit with notably more work confirming the previous reports of hypo-responsiveness in limbic regions) and reward responsiveness. SUMMARY: The recent data are, for the most part, consistent with a view that callous-unemotional traits/psychopathy represents an early appearing neuro-developmental disorder particularly associated with compromised emotional (limbic) functioning. However, some patients presenting with severe antisocial behavior may also show hyper-threat sensitivity, perhaps reflecting trauma exposure, and require different clinical interventions.

Indexed as

AdolescentAdultAffective SymptomsBrainChildConduct DisorderHumansMagnetic Resonance ImagingMaleNeuroimaging

Identifiers

PMID31725420
PMCPMC7374984
OpenAlexW2987394463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.