ArticleJournal of veterinary internal medicine2020
Relationship between serum iohexol clearance, serum SDMA concentration, and serum creatinine concentration in non-azotemic dogs.
Article in Journal of veterinary internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Evaluation of renal microvascular perfusion in dogs with cardiac disease using Superb Microvascular Imaging.Journal of veterinary internal medicine · 2026Article
- Analytical validation, reference interval determination, and diagnostic performance of plasma symmetric dimethylarginine in cattle.Journal of veterinary internal medicine · 2026Article
- Evaluation of Urinary Tubular Biomarkers in Dogs with Myxomatous Mitral Valve Disease Across ACVIM Stages.Veterinary sciences · 2026Article
- Preliminary study investigating the role of estimated glomerular filtration rate, proteinuria and hypertension to inform on chronic kidney disease after acute kidney injury.The Journal of small animal practice · 2026Article
- Serum Creatinine, Cystatin C and Symmetric Dimethylarginine Concentrations and Relationship Between Them in Healthy Small and Miniature Dogs: A Preliminary Study.Animals : an open access journal from MDPI · 2025Article
- Analytical and Quality Control Validation of a Novel Symmetric Dimethylarginine Assay in Dogs and Cats.Veterinary clinical pathology · 2025Article
- Urinary Gamma-Glutamil Transferase as an Early Biomarker of Renal Disease in Dogs with Leishmaniosis.Veterinary sciences · 2025Article
- Renal Biomarkers in Companion Animals-A Review.Animals : an open access journal from MDPI · 2025Review
- Evaluation of renal function in dogs using pulsed Doppler ultrasonography.Open veterinary journal · 2024Article
- Novel renal injury markers in dogs with ehrlichiosis.PloS one · 2023Article
- Prospective evaluation of novel biomarkers of acute kidney injury in dogs following cardiac surgery under cardiopulmonary bypass.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2022Article
- Hyperthyroid cats and their kidneys: a literature review.Australian veterinary journal · 2022Review
- Evaluation of symmetric dimethylarginine and Doppler ultrasonography in the diagnosis of gentamicin-induced acute kidney injury in dogs.Environmental science and pollution research international · 2022Article
- Prospective evaluation of 5 urinary biomarkers as predictors of acute kidney injury in nonazotemic, hospitalized dogs.Journal of veterinary internal medicine · 2021Article
- Alterations of Serum Biochemical and Urinary Parameters in a Canine Population before and after Intravenous Contrast Administration.Veterinary sciences · 2021Article
- A Review of Specific Biomarkers of Chronic Renal Injury and Their Potential Application in Nonclinical Safety Assessment Studies.Toxicologic pathology · 2021Review
- Iron status and erythropoiesis response to darbepoetin alfa in dogs with chronic kidney disease.The Journal of veterinary medical science · 2021Article
- Relationship between serum iohexol clearance, serum SDMA concentration, and serum creatinine concentration in non-azotemic dogs.Journal of veterinary internal medicine · 2020Article
- Symmetric dimethylarginine in dogs with myxomatous mitral valve disease at various stages of disease severity.PloS one · 2020Article
- A Retrospective Evaluation of Serum Symmetric Dimethylarginine Concentration in Dogs With Protein-Losing Enteropathy.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum creatinine and symmetric dimethylarginine (SDMA) are used as surrogate markers of glomerular filtration rate (GFR) in clinical practice. Data pertaining to the correlations between GFR, SDMA, and serum creatinine in client-owned dogs are limited.
objectivesTo describe the relationship between GFR, SDMA, and serum creatinine in a population of client-owned dogs, and to compare clinical utility of SDMA to GFR estimation for detecting pre-azotemic chronic kidney disease. ANIMALS: Medical records of 119 dogs that had GFR estimation performed via serum iohexol clearance between 2012 and 2017.
methodsProspective study using archived samples. GFR, SDMA, and serum creatinine results were reviewed and submitting practices contacted for outcome data. All dogs included in the study population were non-azotemic. Correlations between GFR, SDMA, and serum creatinine were determined by regression analysis. Sensitivity, specificity, and positive and negative likelihood ratios of different cutoffs for SDMA and serum creatinine for detecting decreased GFR were calculated, using a 95% confidence interval.
resultsSerum creatinine and SDMA were moderately correlated with GFR (R CONCLUSIONS AND CLINICAL IMPORTANCE: In non-azotemic dogs being screened for decreased renal function, using a cutoff of >18 μg/dL rather than >14 μg/dL increases the specificity of SDMA, without compromising sensitivity.
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