Evidence map›Paper›PMID 31724947›Full record

ArticleeLife2019

Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics.

Yoshinori Aso, Robert P Ray, Xi Long, Daniel Bushey, Karol Cichewicz, Teri-Tb Ngo, Brandi Sharp, Christina Christoforou, Amy Hu, Andrew L Lemire and 4 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 150 citations in OpenAlex.

  1. Article
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  5. Octopamine instructs head direction plasticity.bioRxiv : the preprint server for biology · 2025
    Article
  6. Neuronal Actin Remodeling and Its Role in Higher Nervous Activity.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Article
  9. CO and NO Coordinate Developmental Neuron Migration.International journal of molecular sciences · 2025
    Article
  10. Article
  11. Compromising Tyrosine Hydroxylase Function Extends and Blunts the Temporal Profile of Reinforcement by Dopamine Neurons inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Cell type-specific driver lines targeting thebioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Yoshinori AsoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID https://orcid.org/0000-0002-2939-1688
Robert P RayJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Xi LongJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID http://orcid.org/0000-0002-0268-8641
Daniel BusheyJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID http://orcid.org/0000-0001-9258-6579
Karol CichewiczDepartment of Biology, University of Virginia, Charlottesville, United States.
Teri-Tb NgoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Brandi SharpJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Christina ChristoforouJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Amy HuJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Andrew L LemireJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Paul TillbergJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Jay HirshDepartment of Biology, University of Virginia, Charlottesville, United States.
Ashok Litwin-KumarDepartment of Neuroscience, Columbia University, New York, United States.ORCID http://orcid.org/0000-0003-2422-6576
Gerald M RubinJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID https://orcid.org/0000-0001-8762-8703
Howard Hughes Medical Institute · USUniversity of Virginia · USColumbia University · US

Funding

Mechanisms of compensation for loss of brain dopamineR01GM084128 · NIGMS · UNIVERSITY OF VIRGINIA · PI HIRSH, JAY · 2009 to 2023
$3.8M
National Science Foundation DBI-1707398NIGMS NIH HHS R01 GM084128NIH HHS R01 GM84128Simons Foundation Global Brain
6 · The paper itself

Abstract

Animals employ diverse learning rules and synaptic plasticity dynamics to record temporal and statistical information about the world. However, the molecular mechanisms underlying this diversity are poorly understood. The anatomically defined compartments of the insect mushroom body function as parallel units of associative learning, with different learning rates, memory decay dynamics and flexibility (Aso and Rubin, 2016). Here, we show that nitric oxide (NO) acts as a neurotransmitter in a subset of dopaminergic neurons in

Indexed as

AnimalsDopamineDopaminergic NeuronsDrosophila melanogasterDrosophila ProteinsLearningMemoryMushroom BodiesNeurotransmitter AgentsNitric OxideOdorantsSmellDopamineDrosophila ProteinsNeurotransmitter AgentsNitric Oxideppl protein, Drosophilaassociative learningcotransmitterD. melanogasterdopaminememory dynamicsmushroom bodyneurosciencenitric oxide

Identifiers

PMID31724947
PMCPMC6948953
OpenAlexW2987761357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.