ArticleeLife2019
Stimulating the hippocampal posterior-medial network enhances task-dependent connectivity and memory.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- A meta-analysis suggests that TMS targeting the hippocampal network selectively improves episodic memory.eLife · 2026Pooled it
- Pooled it
- Effectiveness of Personalized Hippocampal Network-Targeted Stimulation in Alzheimer Disease: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Rhythmic stimulation elicits multiple, concurrent neural responses.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- The hippocampus becomes topographically and functionally specialized along the longitudinal axis with development.Nature communications · 2026Article
- Noninvasive Brain Stimulation Techniques and Their Efficacy in Treating Cognition and Memory in Mild Cognitive Impairment and Alzheimer's Disease-A Systematic Review.Brain sciences · 2026Review
- An Investigation of the Modulating Effects of Sensory Stimulation and Transcranial Magnetic Stimulation on Memory-Related Brain Activity.Brain sciences · 2025Article
- Investigating the effect of task engagement during intertrial rest periods on micro offline gains.Scientific reports · 2025Article
- From Correlation to Causation: Understanding Episodic Memory Networks.Neuroscience bulletin · 2025Review
- Targeting the parietal memory network with tDCS in MCI: study protocol for a randomized controlled trial.Frontiers in human neuroscience · 2025Article
- Causally Probing the Role of the Hippocampus in Fear Discrimination: A Precision Functional Mapping-Guided, Transcranial Magnetic Stimulation Study in Participants With Posttraumatic Stress Symptoms.Biological psychiatry global open science · 2024Article
- Functional and anatomical connectivity predict brain stimulation's mnemonic effects.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Effects of continuous versus intermittent theta-burst TMS on fMRI connectivity.Frontiers in human neuroscience · 2024Article
- Gamma neuromodulation improves episodic memory and its associated network in amnestic mild cognitive impairment: a pilot study.Neurobiology of aging · 2023Article
- Anatomical and Functional Connectivity of Critical Deep Brain Structures and Their Potential Clinical Application in Brain Stimulation.Journal of clinical medicine · 2023Article
- Causally mapping human threat extinction relevant circuits with depolarizing brain stimulation methods.Neuroscience and biobehavioral reviews · 2023Review
- A direct test of competitive versus cooperative episodic-procedural network dynamics in human memory.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Electrophysiological foundations of the human default-mode network revealed by intracranial-EEG recordings during resting-state and cognition.NeuroImage · 2022Article
- Evidence from theta-burst stimulation that age-related de-differentiation of the hippocampal network is functional for episodic memory.Neurobiology of aging · 2022Article
- Early memory deficits and extensive brain network disorganization in theAging brain · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Successful episodic memory involves dynamic increases in activity across distributed hippocampal networks, including the posterior-medial (PMN) and the anterior-temporal (ATN) networks. We tested whether this up-regulation of functional connectivity during memory processing can be enhanced within hippocampal networks by noninvasive stimulation, and whether such task-dependent connectivity enhancement predicts memory improvement. Participants received stimulation targeting the PMN or an out-of-network control location. We compared the effects of stimulation on fMRI connectivity during an autobiographical retrieval task versus during rest within the PMN and the ATN. PMN-targeted stimulation significantly increased connectivity during autobiographical retrieval versus rest within the PMN. This effect was not observed in the ATN, or in either network following control stimulation. Task-dependent increases in connectivity within the medial temporal lobe predicted improved performance of a separate episodic memory test. It is therefore possible to enhance the task-dependent regulation of hippocampal network connectivity that supports memory processing using noninvasive stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.