Evidence map›Paper›PMID 31724436›Full record

ArticleThe British journal of radiology2020

Potential for dose reduction in CT emphysema densitometry with post-scan noise reduction: a phantom study.

Hendrik Joost Wisselink, Gert Jan Pelgrim, Mieneke Rook, Maarten van den Berge, Kees Slump, Yeshu Nagaraj, Peter van Ooijen, Matthijs Oudkerk, Rozemarijn Vliegenthart

Abstract read
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Article in The British journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hendrik Joost WisselinkUniversity of Groningen, University Medical Center Groningen, Center for Medical Imaging, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-1706-5076
Gert Jan PelgrimUniversity of Groningen, University Medical Center Groningen, Center for Medical Imaging, Groningen, The Netherlands.
Mieneke RookUniversity of Groningen, University Medical Center Groningen, Center for Medical Imaging, Groningen, The Netherlands.
Maarten van den BergeDepartment of Pulmonology, University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, the Netherlands.
Kees SlumpMIRA: Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands.
Yeshu NagarajUniversity of Groningen, University Medical Center Groningen, Center for Medical Imaging, Groningen, The Netherlands.
Peter van OoijenUniversity of Groningen, University Medical Center Groningen, Center for Medical Imaging, Groningen, The Netherlands.
Matthijs OudkerkUniversity of Groningen, University Medical Center Groningen, Center for Medical Imaging, Groningen, The Netherlands.
Rozemarijn VliegenthartUniversity of Groningen, University Medical Center Groningen, Center for Medical Imaging, Groningen, The Netherlands.

Funding

Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
NHLBI NIH HHS U01 HL089856
6 · The paper itself

Abstract

objectiveThe aim of this phantom study was to investigate the effect of scan parameters and noise suppression techniques on the minimum radiation dose for acceptable image quality for CT emphysema densitometry.

methodsThe COPDGene phantom was scanned on a third generation dual-source CT system with 16 scan setups (CTDI

resultsIn total, 384 scan reconstructions were analyzed. Decreasing radiation dose resulted in an exponential increase of the overlap in normalized histograms of CT density. The overlap was 11-91% for the lowest dose setting (CTDI

conclusionCT density histogram overlap can quantify the degree of discernibility of emphysema and healthy lung tissue. Noise suppression software, IR, and soft reconstruction kernels substantially decrease the dose required for acceptable image quality. ADVANCES IN KNOWLEDGE: Noise suppression software, IR, and soft reconstruction kernels allow radiation dose reduction by 85% while still allowing differentiation between emphysema and normal lung tissue.

Indexed as

Phantoms, ImagingRadiation DosageHumansPulmonary EmphysemaRadiographic Image Interpretation, Computer-AssistedTomography, X-Ray Computed

Identifiers

PMID31724436
PMCPMC6948080

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.