ArticleMolecular genetics & genomic medicine2020
Investigation of the STOX1 polymorphism on lumbar disc herniation.
Article in Molecular genetics & genomic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Assessment of MIR3142HG genetic polymorphisms and the susceptibility of lumbar disc herniation in the Chinese population.Scientific reports · 2024Article
- Genetic predisposition ofCell cycle (Georgetown, Tex.) · 2024Article
- Association of LINC-PINT polymorphisms with lumbar disc herniation risk among Chinese Han population: a case control study.Journal of orthopaedic surgery and research · 2023Article
- Association betweenCell cycle (Georgetown, Tex.) · 2022Article
- Curative Effects of Remote Home Management Combined with Feng's Spinal Manipulation on the Treatment of Elderly Patients with Lumbar Disc Herniation.Journal of healthcare engineering · 2022Article
- Investigation of the STOX1 polymorphism on lumbar disc herniation.Molecular genetics & genomic medicine · 2020Article
- Clinical and pathological considerations in lumbar herniated disc associated with inflammatory lesions.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLumbar disc herniation (LDH) is a common musculoskeletal disorder affliction and associated with several genes polymorphism. Storkhead box 1 (STOX1) gene is a transcriptional factor related with several signaling pathways including inflammatory pathway. However, little is known about single-nucleotide polymorphisms (SNPs) of STOX1 associated with LDH risk.
methodsWe conducted a case-control study among 508 LDH cases and well-matched 508 controls, and six candidate SNPs in STOX1 were genotyped by Agena MassARRAY. Chi-squared test, genetic model, and haploview analysis were used to evaluate associations. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression.
resultsIn the allelic model analysis, we found the minor allele "T" of rs7903209 and "A" of rs4472827 were associated with an increased risk of LDH (p = .029, p = .016). Furthermore, in the genotype model analysis, rs7903209 polymorphism was associated with the increased susceptibility of LDH based on dominant (p = .033) and additive model (p = .024); and rs4472827 variant was found to play a harmful role in the LDH risk based on genotype (p = .014), dominant (p = .012), and additive model (p = .015). In the haplotype analysis, the haplotype "GT" in block (rs10998461 and rs10998468) decreased LDH risk (OR = 0.7, 95% CI = 0.52-0.93, p = .016). Functional assessment indicated that rs7903209 and rs4472827 polymorphisms may influence the expression of STOX1.
conclusionOur results provide evidence for polymorphisms of rs7903209 and rs4472827 in STOX1 associated with LDH risk in Chinese Han population.
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