Evidence map›Paper›PMID 31724120›Full record

ArticleJournal of autism and developmental disorders2020

Buspirone for the Treatment of Generalized Anxiety Disorder in Williams Syndrome: A Case Series.

Robyn P Thom, Christopher J Keary, Jessica L Waxler, Barbara R Pober, Christopher J McDougle

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Williams syndrome.Nature reviews. Disease primers · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Robyn P ThomMassachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA.
Christopher J KearyMassachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA.
Jessica L WaxlerMassachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA.
Barbara R PoberMassachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA.
Christopher J McDougleMassachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA. cmcdougle@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-6229-9293
Harvard University · USMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Co-morbid anxiety disorders, including generalized anxiety disorder (GAD), are highly prevalent among individuals with Williams syndrome (WS). However, reports of the pharmacologic treatment of only a limited number of previous anxiety disorders in WS have appeared in the literature. Here, we review the case histories of three adolescents/young adults with WS and the treatment course of co-morbid GAD with buspirone. Treatment with buspirone was well-tolerated and resulted in sustained response in all three cases. Common medical disorders in WS are highlighted with regards to safe and appropriate pharmacologic treatment of GAD. Buspirone's generally benign side effect profile is a major benefit of its use for treating GAD in individuals with WS.

Indexed as

AdolescentAnti-Anxiety AgentsAnxiety DisordersBuspironeComorbidityFemaleHumansWilliams SyndromeYoung AdultAnti-Anxiety AgentsBuspironeAnxietyBuspironeWilliams syndrome

Identifiers

PMID31724120
OpenAlexW2985739679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.