ReviewCurrent treatment options in neurology2019
Delirium Management in the ICU.
Review in Current treatment options in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Trazodone vs Quetiapine vs Placebo for the Treatment of ICU Delirium: A Randomized Controlled Trial (The TraQ Study)
Trazodone vs. Quetiapine for the Treatment of ICU Delirium: A Prospective Observational Pilot Study
From Reactive Management to Proactive Prevention: Implementing a Multi-Component Bundle to Reduce Delirium in the Aging CICU Population
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Biospecimens and Biomarkers.Neurocritical care · 2024Pooled it
- Effect of early cognitive interventions on delirium in critically ill patients: a systematic review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2020Pooled it
- Physical restraint use in a United States intensive care unit-a retrospective cross sectional, single center cohort study from 2008 to 2022.Lancet regional health. Americas · 2026Article
- Early goal-directed sedation with dexmedetomidine is associated with lower delirium rate in mechanically ventilated patients.BMC anesthesiology · 2026Article
- Association between the confusion assessment method for the intensive care unit (CAM-ICU) and prolonged mechanical ventilation following major cardiac surgery.European journal of medical research · 2026Article
- Association Between Preoperative Sleep Disturbance and Postoperative Delirium in Adults Undergoing Elective Surgery.Cureus · 2025Article
- Strategies to prevent postoperative delirium: a comprehensive evaluation of anesthesia selection and drug intervention.Frontiers in psychiatry · 2024Review
- Validation to Spanish of nursing assessment scale for early diagnosis of delirium - Nu-DESC.Investigacion y educacion en enfermeria · 2023Article
- Effects of immersive virtual reality on sensory overload in a random sample of critically ill patients.Frontiers in medicine · 2023Article
- Pharmacokinetics of Haloperidol in Critically Ill Patients: Is There an Association with Inflammation?Pharmaceutics · 2022Article
- Cerebrospinal fluid catecholamines in delirium and dementia.Brain communications · 2021Article
- Cluster nursing can reduce postoperative delirium and improve the negative emotions and quality of life of elderly ICU patients.American journal of translational research · 2021Article
- A data-driven evaluation of a train-the-trainer program for delirium management in ICUs: a mixed-methods study integrating multidimensional outcome metrics and qualitative insights.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewDelirium occurs frequently in critically ill patients and is associated with adverse outcomes in both the short and long term. In this review, we aim to highlight recent study findings on the prevention and treatment of delirium, provide additional recommendations based on expert guidelines, and indicate knowledge gaps deserving of future study. RECENT
findingsMulticomponent non-pharmacologic interventions have been shown to be efficacious in non-ICU populations, and multicomponent strategies such as the ABCDEF bundle have been adopted in the ICU with several studies showing a potential benefit in delirium outcomes. Meanwhile, two negative randomized clinical trials of antipsychotics in ICU patients (REDUCE and MIND-USA) have provided strong evidence that such medications neither prevent nor shorten the duration of delirium. Other potential pharmacologic treatments with promising results include dexmedetomidine and, to a lesser extent, ramelteon, but more data is needed before they may be more definitively recommended. Effective and proven delirium management strategies are still largely lacking, though there is evidence to support the use of some non-pharmacologic interventions. Future studies of novel non-pharmacologic interventions and pharmacologic agents other than antipsychotics are warranted.
Indexed as
Identifiers
31724092What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.