ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Varying Effects of APOE Alleles on Extreme Longevity in European Ethnicities.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians.International journal of molecular sciences · 2026Review
- Genetic associations with longevity in a Calabrian cohort: an exploratory genome-wide study.GeroScience · 2026Article
- Race and ethnicity dynamics in survival to 100 years in the United States.Journal of internal medicine · 2025Article
- Lack of association between common polymorphisms associated with successful aging and longevity in the population of Sardinian Blue Zone.Scientific reports · 2024Article
- To Be Frail or Not to Be Frail: This Is the Question-A Critical Narrative Review of Frailty.Journal of clinical medicine · 2024Review
- Personalized medicine in old age psychiatry and Alzheimer's disease.Frontiers in psychiatry · 2024Review
- How are APOE4, changes in body weight, and longevity related? Insights from a causal mediation analysis.Frontiers in aging · 2024Article
- The Phenotypic Characterization of the Oldest Italian Man from December 28, 2020, to September 23, 2021, A.T., Strengthens the Idea That the Immune System can Play a Key Role in the Attainment of Extreme Longevity.Journal of clinical medicine · 2023Article
- Research gaps and opportunities in precision nutrition: an NIH workshop report.The American journal of clinical nutrition · 2022Article
- How Important Are Genes to Achieve Longevity?International journal of molecular sciences · 2022Review
- Age and Gender-related Variations of Molecular and Phenotypic Parameters in A Cohort of Sicilian Population: from Young to Centenarians.Aging and disease · 2021Article
- Precision Nutrition for Alzheimer's Prevention inNutrients · 2021Review
- When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of APOE ε2.The journals of gerontology. Series B, Psychological sciences and social sciences · 2020Article
- Genetics of frailty: A longevity perspective.Translational research : the journal of laboratory and clinical medicine · 2020Review
- Studying the Interplay Between Apolipoprotein E and Education on Cognitive Decline in Centenarians Using Bayesian Beta Regression.Frontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
APOE is a well-studied gene with multiple effects on aging and longevity. The gene has three alleles: e2, e3, and e4, whose frequencies vary by ethnicity. While the e2 is associated with healthy cognitive aging, the e4 allele is associated with Alzheimer's disease and early mortality and therefore its prevalence among people with extreme longevity (EL) is low. Using the PopCluster algorithm, we identified several ethnically different clusters in which the effect of the e2 and e4 alleles on EL changed substantially. For example, PopCluster discovered a large group of 1,309 subjects enriched of Southern Italian genetic ancestry with weaker protective effect of e2 (odds ratio [OR] = 1.27, p = .14) and weaker damaging effect of e4 (OR = 0.82, p = .31) on the phenotype of EL compared to other European ethnicities. Further analysis of this cluster suggests that the odds for EL in carriers of the e4 allele with Southern Italian genetic ancestry differ depending on whether they live in the United States (OR = 0.29, p = .009) or Italy (OR = 1.21, p = .38). PopCluster also found clusters enriched of subjects with Danish ancestry with varying effect of e2 on EL. The country of residence (Denmark or United States) appears to change the odds for EL in the e2 carriers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.