Evidence map›Paper›PMID 31723936›Full record

ArticleMaterials today. Bio2019

Acoustic modification of collagen hydrogels facilitates cellular remodeling.

E G Norris, D Dalecki, D C Hocking

Open access · goldAbstract read
In one paragraph

Article in Materials today. Bio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

E G NorrisDepartment of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
D DaleckiDepartment of Biomedical Engineering, University of Rochester, Rochester, NY 14627, USA.
D C HockingDepartment of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
University of Rochester · US

Funding

Ultrasound standing wave fields for vascular tissue engineeringR01EB018210 · NIBIB · UNIVERSITY OF ROCHESTER · PI DALECKI, DIANE, HOCKING, DENISE C · 2014 to 2017
$1.9M
Fibronectin Mimetics and Synergistic Ultrasound Therapy for Wound Healing in AgingR01AG058746 · NIA · UNIVERSITY OF ROCHESTER · PI DALECKI, DIANE, HOCKING, DENISE C · 2018 to 2022
$1.7M
NIA NIH HHS R01 AG058746NIBIB NIH HHS R01 EB018210
6 · The paper itself

Abstract

Developing tunable biomaterials that have the capacity to recreate the physical and biochemical characteristics of native extracellular matrices (ECMs) with spatial fidelity is important for a variety of biomedical, biological, and clinical applications. Several factors have made the ECM protein, collagen I, an attractive biomaterial, including its ease of isolation, low antigenicity and toxicity, and biodegradability. However, current collagen gel formulations fail to recapitulate the range of collagen structures observed in native tissues, presenting a significant challenge in achieving the full potential of collagen-based biomaterials. Collagen fiber structure can be manipulated in vitro through mechanical forces, environmental factors, or thermal mechanisms. Here, we describe a new ultrasound-based fabrication technology that exploits the ability of ultrasound to generate localized mechanical forces to control the collagen fiber microstructure non-invasively. The results indicate that exposing soluble collagen to ultrasound (7.8 or 8.8 MHz; 3.2-10 W/cm

Indexed as

AcousticsBiomaterialsExtracellular matrixTissue engineeringUltrasound

Identifiers

PMID31723936
PMCPMC6853634
OpenAlexW2963765645

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.