ArticleAcute and critical care2019
Characteristics, management and clinical outcomes of patients with sepsis: a multicenter cohort study in Korea.
Article in Acute and critical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Early management of adult sepsis and septic shock: Korean clinical practice guidelines.Acute and critical care · 2024Guideline
- Mortality among adult patients with sepsis and septic shock in Korea: a systematic review and meta-analysis.Clinical and experimental emergency medicine · 2023Pooled it
- Factors Associated with Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Regional Adherence to Early Sepsis Management Bundle and Associated Mortality in Hong Kong Between 2009-2018.Open forum infectious diseases · 2026Article
- Remimazolam-based anesthesia in sepsis patients: a retrospective cohort study of hemodynamic stability and postoperative outcomes.Frontiers in medicine · 2026Article
- Review
- Effects of adjunctive dobutamine on outcomes among patients with septic shock: a propensity score matching analysis.The Korean journal of internal medicine · 2025Observational
- The 6-hour window: is the sepsis transfer guideline enough?Acute and critical care · 2025Article
- Evaluating the diagnostic performance of adult sepsis event criteria in the emergency department: impact of including isolated serum lactate elevations.Journal of intensive care · 2025Article
- Closed intensive care units and sepsis patient outcomes: a secondary analysis of data from a multicenter prospective observational study in South Korea.Acute and critical care · 2025Article
- Culture-negative sepsis may be a different entity from culture-positive sepsis: a prospective nationwide multicenter cohort study.Critical care (London, England) · 2024Article
- Challenges of implementing the hour-1 sepsis bundle: a qualitative study from a secondary hospital in Indonesia.Acute and critical care · 2024Article
- Deficits in blood culture collection in the emergency department if sepsis is suspected: results of a retrospective cohort study.Infection · 2024Article
- ChatGPT Predicts In-Hospital All-Cause Mortality for Sepsis: In-Context Learning with the Korean Sepsis Alliance Database.Healthcare informatics research · 2024Article
- Development and validation of an interpretable model for predicting sepsis mortality across care settings.Scientific reports · 2024Article
- Pre-Sepsis Length of Hospital Stay and Mortality: A Nationwide Multicenter Cohort Study.Journal of Korean medical science · 2024Article
- Early Prediction of Mortality for Septic Patients Visiting Emergency Room Based on Explainable Machine Learning: A Real-World Multicenter Study.Journal of Korean medical science · 2024Article
- Clinical effects of bacteremia in sepsis patients with community-acquired pneumonia.BMC infectious diseases · 2023Article
- Impact of sepsis on Eastern Cooperative Oncology Group performance status among fully ambulatory patients: a prospective nationwide multicenter cohort.Journal of thoracic disease · 2023Article
- Antibiogram of Multidrug-Resistant Bacteria Based on Sepsis Onset Location in Korea: A Multicenter Cohort Study.Journal of Korean medical science · 2023Observational
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Authors and funding
22 authors at 16 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMortality rates associated with sepsis have increased progressively in Korea, but domestic epidemiologic data remain limited. The objective of this study was to investigate the characteristics, management and clinical outcomes of sepsis patients in Korea.
methodsThis study is a multicenter retrospective cohort study. A total of 64,021 adult patients who visited an emergency department (ED) within one of the 19 participating hospitals during a 1-month period were screened for eligibility. Among these, patients diagnosed with sepsis based on the third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) were included in the study.
resultsUsing the Sepsis-3 criteria, 977 sepsis patients were identified, among which 36.5% presented with septic shock. The respiratory system (61.8%) was the most common site of infection. The pathogen involved was identified in 444 patients (45.5%) and multi-drug resistance (MDR) pathogens were isolated in 171 patients. Empiric antibiotic therapy was appropriate in 68.6% of patients, but the appropriateness was significantly reduced in infections associated with MDR pathogens as compared with non-MDR pathogens (58.8% vs. 76.0%, P<0.001). Hospital mortality was 43.2% and 18.5% in sepsis patients with and without shock, respectively. Of the 703 patients who survived to discharge, 61.5% were discharged to home and 38.6% were transferred to other hospitals or facilities.
conclusionsThis study found the prevalence of sepsis in adult patients visiting an ED in Korea was 1.5% (15.2/1,000 patients). Patients with sepsis, especially septic shock, had a high mortality and were often referred to step-down centers after acute and critical care.
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