ArticleAcute and critical care2019
Utility of the early lactate area score as a prognostic marker for septic shock patients in the emergency department.
Article in Acute and critical care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Clinical and microbiological characteristics of bacteremia in pediatric intensive care unit: a retrospective analytical observational study.BMC pediatrics · 2025Observational
- Early lactate dynamics for short-term mortality in emergency department sepsis.BMC emergency medicine · 2025Observational
- Evaluation of Hypoxia Markers in Critically Ill Patients Categorized by Their Burden of Organ Dysfunction: A Novel Approach to Detect Pathophysiological and Clinical Relevance in a Secondary Analysis of a Prospective Observational Study.International journal of molecular sciences · 2025Observational
- Article
- Mortality Prediction by Kinetic Parameters of Lactate and S-Adenosylhomocysteine in a Cohort of Critically Ill Patients.International journal of molecular sciences · 2024Article
- Using time-course as an essential factor to accurately predict sepsis-associated mortality among patients with suspected sepsis.Biomedical journal · 2024Article
- Hierarchical Capability in Distinguishing Severities of Sepsis via Serum Lactate: A Network Meta-Analysis.Biomedicines · 2024Review
- Prediction of intensive care unit mortality: Interest of serum lactates.La Tunisie medicale · 2023Observational
- Serial evaluation of the serum lactate level with the SOFA score to predict mortality in patients with sepsis.Scientific reports · 2023Observational
- An integrated wearable microneedle array for the continuous monitoring of multiple biomarkers in interstitial fluid.Nature biomedical engineering · 2022Article
- Increased normalized lactate load is associated with higher mortality in both sepsis and non-sepsis patients: an analysis of the MIMIC-IV database.BMC anesthesiology · 2022Article
- Usefulness of presepsin in predicting the prognosis of patients with sepsis or septic shock: a retrospective cohort study.Yeungnam University journal of medicine · 2021Article
- A Graphene-Based Enzymatic Biosensor Using a Common-Gate Field-Effect Transistor for L-Lactic Acid Detection in Blood Plasma Samples.Sensors (Basel, Switzerland) · 2021Article
- Mortality prediction using a novel combination of biomarkers in the first day of sepsis in intensive care units.Scientific reports · 2021Observational
- Association between normalized lactate load and mortality in patients with septic shock: an analysis of the MIMIC-III database.BMC anesthesiology · 2021Article
- Recent lactate findings: is repeated serum lactate testing necessary in septic shock patients?Acute and critical care · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe current Surviving Sepsis Campaign guidelines recommend the remeasurement of lactate levels if the initial lactate level is elevated; however, the prognostic value of lactate kinetics is limited and inconsistent. We attempted to determine the efficacy of the lactate area score (calculated from repeated lactate measurements during initial resuscitation) as a prognostic marker of septic shock in the emergency department (ED).
methodsWe performed a retrospective study of adult patients with septic shock in the ED of a single tertiary medical center. Serial lactate levels were measured five times within 12 hours. We also compared the initial lactate level, maximum lactate level, and lactate area score. The lactate area score was defined as the sum of the area under the curve measured at 2, 4, 6, and 12 hours following the initial measurement.
resultsA total of 362 patients were enrolled in this study, and the overall 28-day mortality was 31.8%. The lactate area score of serial lactate levels as well as the initial (median [interquartile range], 4.9 [3.4 to 10.5]; P=0.003) and maximum (7.3 [4.2 to 13.2]; P<0.001) lactate levels were significantly higher in the non-survivor group. However, in multivariate analysis, only the lactate area score (odds ratio, 1.013; 95% confidence interval, 1.007 to 1.019) was significantly associated with 28-day mortality.
conclusionsThe early lactate area score may be a possible prognostic marker for predicting the 28-day mortality of adult septic shock patients. Further prospective interventional studies should be conducted to validate our results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.