ArticleKorean journal of critical care medicine2017
Serum Albumin as a Biomarker of Poor Prognosis in the Pediatric Patients in Intensive Care Unit.
Article in Korean journal of critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 20 citations in OpenAlex.
- Factors Associated with Short-Term Clinical Outcomes in ICU Patients with Carbapenem-ResistantJournal of clinical medicine · 2026Article
- Clinical value of neutrophil-to-lymphocyte ratio and D-dimer in predicting the efficacy of minocycline for pediatric Mycoplasma pneumoniae pneumonia.Frontiers in pediatrics · 2026Article
- Hypoalbuminemia is associated with adverse outcomes in critically ill children with cancer.Frontiers in oncology · 2025Article
- Prognostic value of the lactate dehydrogenase-to-albumin ratio for predicting mortality in critically ill pediatric patients: a retrospective cohort study.Frontiers in pediatrics · 2025Article
- Factors Associated with In-Hospital Mortality in Adult Patients with Community-AcquiredIranian journal of pathology · 2025Article
- Association between serum albumin levels at admission and clinical outcomes in pediatric intensive care units: a multi-center study.BMC pediatrics · 2024Article
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- Prognostic factors and models to predict pediatric sepsis mortality: A scoping review.Frontiers in pediatrics · 2022Article
- Overview of Albumin Physiology and its Role in Pediatric Diseases.Current gastroenterology reports · 2021Review
- Low albumin levels are associated with mortality in the critically ill: A retrospective observational study in a multidisciplinary intensive care unit.The Southern African journal of critical care : the official journal of the Critical Care Society · 2020Article
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Authors and funding
9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSerum albumin as an indicator of the disease severity and mortality is suggested in adult patients, but its role in pediatric patients has not been established. The objectives of this study are to investigate the albumin level as a biomarker of poor prognosis and to compare it with other mortality predictive indices in children in intensive care unit (ICU).
methodsMedical records of 431 children admitted to the ICU at Severance Hospital from January 1, 2012 to December 31, 2015 were retrospectively analyzed. Children who expired within 24 hours after ICU admission, children with hepatic or renal failure, and those who received albumin replacement before ICU admission were excluded.
resultsThe children with hypoalbuminemia had higher 28-day mortality rate (24.60% vs. 9.28%, P < 0.001), Pediatric Index of Mortality (PIM) 3 score (9.23 vs. 8.36, P < 0.001), Pediatric Risk of Mortality (PRISM) III score (7.0 vs. 5.0, P < 0.001), incidence of septic shock (12% vs. 3%, P < 0.001), C-reactive protein (33.0 mg/L vs. 5.8 mg/L, P < 0.001), delta neutrophil index (2.0% vs. 0.6%, P < 0.001), lactate level (1.6 mmol/L vs. 1.2 mmol/L, P < 0.001) and lower platelet level (206,000/μl vs. 341,000/μl, P < 0.001) compared to the children with normal albumin level. PIM 3 (r = 0.219, P < 0.001) and PRISM III (r = 0.375, P < 0.001) were negatively correlated with serum albumin level, respectively.
conclusionsOur results highlight that hypoalbuminemia can be a biomarker of poor prognosis including mortality in the children in ICU.
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