Evidence map›Paper›PMID 31723575›Full record

ArticleIEEE transactions on computational imaging2019

PET Image Deblurring and Super-Resolution with an MR-Based Joint Entropy Prior.

Tzu-An Song, Fan Yang, Samadrita Roy Chowdhury, Kyungsang Kim, Keith A Johnson, Georges El Fakhri, Quanzheng Li, Joyita Dutta

Abstract read
In one paragraph

Article in IEEE transactions on computational imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. PET image super-resolution using generative adversarial networks.Neural networks : the official journal of the International Neural Network Society · 2020
    Article
  10. Super-Resolution PET Imaging Using Convolutional Neural Networks.IEEE transactions on computational imaging · 2020
    Article
  11. PET image denoising using unsupervised deep learning.European journal of nuclear medicine and molecular imaging · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tzu-An SongDepartment of Electrical and Computer Engineering, University of Massachusetts Lowell, Lowell, MA, 01854, USA; Massachusetts General Hospital, Boston, MA, 02114, USA.
Fan YangDepartment of Electrical and Computer Engineering, University of Massachusetts Lowell, Lowell, MA, 01854, USA; Massachusetts General Hospital, Boston, MA, 02114, USA.
Samadrita Roy ChowdhuryDepartment of Electrical and Computer Engineering, University of Massachusetts Lowell, Lowell, MA, 01854, USA; Massachusetts General Hospital, Boston, MA, 02114, USA.
Kyungsang KimMassachusetts General Hospital, Boston, MA, 02114, USA.
Keith A JohnsonMassachusetts General Hospital, Boston, MA, 02114, USA.
Georges El FakhriMassachusetts General Hospital, Boston, MA, 02114, USA.
Quanzheng LiMassachusetts General Hospital, Boston, MA, 02114, USA.
Joyita DuttaDepartment of Electrical and Computer Engineering, University of Massachusetts Lowell, Lowell, MA, 01854, USA; Massachusetts General Hospital, Boston, MA, 02114, USA.

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5M
Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
Tau Quantitation in AD with High Resolution MRI and PETK01AG050711 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI DUTTA, JOYITA · 2015 to 2019
$650k
NIA NIH HHS K01 AG050711NIA NIH HHS P30 AG062421NIBIB NIH HHS P41 EB022544
6 · The paper itself

Abstract

The intrinsically limited spatial resolution of PET confounds image quantitation. This paper presents an image deblurring and super-resolution framework for PET using anatomical guidance provided by high-resolution MR images. The framework relies on image-domain post-processing of already-reconstructed PET images by means of spatially-variant deconvolution stabilized by an MR-based joint entropy penalty function. The method is validated through simulation studies based on the BrainWeb digital phantom, experimental studies based on the Hoffman phantom, and clinical neuroimaging studies pertaining to aging and Alzheimer's disease. The developed technique was compared with direct deconvolution and deconvolution stabilized by a quadratic difference penalty, a total variation penalty, and a Bowsher penalty. The BrainWeb simulation study showed improved image quality and quantitative accuracy measured by contrast-to-noise ratio, structural similarity index, root-mean-square error, and peak signal-to-noise ratio generated by this technique. The Hoffman phantom study indicated noticeable improvement in the structural similarity index (relative to the MR image) and gray-to-white contrast-to-noise ratio. Finally, clinical amyloid and tau imaging studies for Alzheimer's disease showed lowering of the coefficient of variation in several key brain regions associated with two target pathologies.

Indexed as

deblurringjoint entropyMRpartial volume correctionPETsuper-resolution

Identifiers

PMID31723575
PMCPMC6853071

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.