Evidence map›Paper›PMID 31723547›Full record

ArticleNanotheranostics2019

Theranostic nanoparticles enhance the response of glioblastomas to radiation.

Wei Wu, Jessica L Klockow, Suchismita Mohanty, Kimberly S Ku, Maryam Aghighi, Stavros Melemenidis, Zixin Chen, Kai Li, Goreti Ribeiro Morais, Ning Zhao and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanotheranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Wei WuDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Jessica L KlockowDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Suchismita MohantyDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Kimberly S KuDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Maryam AghighiDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Stavros MelemenidisDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.
Zixin ChenDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Kai LiDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Goreti Ribeiro MoraisInstitute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford, UK.
Ning ZhaoDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Jürgen SchlegelDepartment of Neuropathology, School of Medicine, Technical University of Munich, Munich, Germany.
Edward E GravesDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Jianghong RaoDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Paul M LoadmanInstitute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford, UK.
Robert A FalconerInstitute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford, UK.
Sudip MukherjeeDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Frederick T ChinDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Heike E Daldrup-LinkDepartment of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA, USA.
Stanford University · USUniversity of Bradford · GB

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
Nano Characterization and Nano Fabrication CoreU54CA199075 · NCI · STANFORD UNIVERSITY · PI SINCLAIR, ROBERT · 2015 to 2019
$9.6M
Stanford Molecular Imaging Scholars (SMIS) ProgramT32CA118681 · NCI · STANFORD UNIVERSITY · PI CRAIG S LEVIN · 2016 to 2026
$4.3M
NCI NIH HHS P30 CA124435NCI NIH HHS T32 CA118681NCI NIH HHS U54 CA199075
6 · The paper itself

Abstract

Despite considerable progress with our understanding of glioblastoma multiforme (GBM) and the precise delivery of radiotherapy, the prognosis for GBM patients is still unfavorable with tumor recurrence due to radioresistance being a major concern. We recently developed a cross-linked iron oxide nanoparticle conjugated to azademethylcolchicine (CLIO-ICT) to target and eradicate a subpopulation of quiescent cells, glioblastoma initiating cells (GICs), which could be a reason for radioresistance and tumor relapse. The purpose of our study was to investigate if CLIO-ICT has an additive therapeutic effect to enhance the response of GBMs to ionizing radiation.

Indexed as

Theranostic NanomedicineAnimalsBrainBrain NeoplasmsCaspase 3Cell Line, TumorCombined Modality TherapyDeoxyadenosinesDrug CarriersFemaleFerric CompoundsGlioblastomaHumansKaplan-Meier EstimateMagnetic Resonance ImagingMetal NanoparticlesazadideoxyadenosineCaspase 3DeoxyadenosinesDrug CarriersFerric Compoundsferric oxideferumoxytolglioblastomaglioblastoma initiating cellsimagingradiation therapytheranostic nanoparticle

Identifiers

PMID31723547
PMCPMC6838141
OpenAlexW2976671303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.