ReviewCureus2019
Utility of Patch Testing and Lymphocyte Transformation Testing in the Evaluation of Metal Allergy in Patients with Orthopedic Implants.
Review in Cureus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- No difference in patient reported outcome and inflammatory response after coated and uncoated total knee arthroplasty - a randomized controlled study.BMC musculoskeletal disorders · 2023Trial
- Increased 30-Day Readmission Rates in Total Knee Arthroplasty Patients Using Hypoallergenic Implants.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Outcomes of Metal Hypersensitivity in Knee Arthroplasty: A Systematic Review of the Literature.Arthroplasty today · 2026Article
- Suspected Hypersensitivity Reaction to Titanium Screws Following Kalish Osteotomy for Hallux Valgus.Cureus · 2026Article
- Allergic Reaction to Titanium Alloy Osteosynthesis Implants: A Case Report of Three Patients.Life (Basel, Switzerland) · 2026Article
- Existing and Novel Assessment Methods for Metal Sensitivity in Elective Lower-Limb Arthroplasty-A Scoping Review.Arthroplasty today · 2024Article
- Orthopedic Dermatopathies: Skin Manifestations in Orthopedic Conditions.Journal of orthopaedics and sports medicine · 2024Article
- Magnetic Resonance Safety Evaluation of a Novel Alumina Matrix Composite Ceramic Knee and Image Artifact Comparison to a Metal Knee Implant of Analogous Design.Arthroplasty today · 2023Article
- Metal hypersensitivity in hip, knee and spine surgery.Postepy dermatologii i alergologii · 2023Review
- Hypersensitivity reactions to metals in spine surgery.Musculoskeletal surgery · 2023Review
- Allergic reaction and metal hypersensitivity after shoulder joint replacement.Musculoskeletal surgery · 2023Article
- Cross-Reactivity of Intraoral Allergic Contact Mucositis in the Nickel-Sensitized Ear Model of Metal Allergy.International journal of molecular sciences · 2023Article
- Poor Correlation Among Metal Hypersensitivity Testing Modalities and Inferior Patient-Reported Outcomes After Primary and Revision Total Knee Arthroplasties.Arthroplasty today · 2022Article
- Nickel contamination after minimally-invasive repair of pectus excavatum persists after bar removal.PloS one · 2022Article
- No Clinical or Radiographic Differences Between Cemented Cobalt-Chromium and Titanium-Niobium Nitride Mobile-Bearing Unicompartmental Knee Arthroplasty.Indian journal of orthopaedics · 2021Article
- Metal allergy in primary and revision total knee arthroplasty : a scoping review and evidence-based practical approach.Bone & joint open · 2021Article
- Metal Hypersensitivity in Joint Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2021Review
- Metal allergy after the Nuss procedure for pectus excavatum: a review.Postepy dermatologii i alergologii · 2020Review
- Delayed Metal Hypersensitivity from Surgical Clips Causing Progressive Neuropathy.CRSLS : MIS case reports from SLSArticle
- Allergic Sensitization to Nickel and Implanted Metal Devices: A Perspective.Dermatitis : contact, atopic, occupational, drugArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Total joint arthroplasties are increasingly common orthopedic procedures performed throughout the United States. Implant failure after these procedures occurs due to a number of causes such as infection or mechanical problems, with metal hypersensitivity being an area of growing interest. The nature and mechanism of a causative relationship between metal hypersensitivity and implant failure have been unclear as it is not known whether implant failure occurs due to a previous metal allergy or metal allergy results from secondary sensitization via metal exposure in existing failing implants. Overall, there appears to be growing support and evidence for metal-hypersensitive patients having worse outcomes with regard to total hip and knee arthroplasties. However, there are conflicting recommendations (outside of Nuss procedures) for pre-implant testing for metal hypersensitivity as testing has not consistently been shown to change patient outcomes.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.