Evidence map›Paper›PMID 31723439›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Serum neurofilament light chain concentration in a phase 1/2 trial of autologous mesenchymal stem cell transplantation.

Laura E Baldassari, Sarah M Planchon, Robert A Bermel, Kunio Nakamura, Elizabeth Fisher, Jenny Feng, Ken E Sakaie, Daniel Ontaneda, Jeffrey A Cohen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  4. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Laura E BaldassariMellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, USA.ORCID https://orcid.org/0000-0003-1795-1542
Sarah M PlanchonMellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, USA.ORCID https://orcid.org/0000-0002-5093-0754
Robert A BermelMellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, USA.
Kunio NakamuraBiomedical Engineering, Cleveland Clinic, USA.
Elizabeth FisherBiogen, USA.
Jenny FengMellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, USA.ORCID https://orcid.org/0000-0003-3700-7823
Ken E SakaieImaging Institute, Cleveland Clinic, USA.
Daniel OntanedaMellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, USA.ORCID https://orcid.org/0000-0002-2838-9148
Jeffrey A CohenMellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, USA.ORCID https://orcid.org/0000-0001-9245-9772
Cleveland Clinic · USBiogen (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum neurofilament light chain concentration is a proposed biomarker of axonal injury in multiple sclerosis. Mesenchymal stem cells have anti-inflammatory and repair-promoting activities, making them of interest for potential multiple sclerosis treatment.

objectivesThe purpose of this study was to assess correlation of serum neurofilament light chain concentration and measures of multiple sclerosis disease activity/severity, longitudinal stability of serum neurofilament light chain concentration, and treatment effect of mesenchymal stem cell transplantation on serum neurofilament light chain concentration.

methodsTwenty-four multiple sclerosis patients underwent intravenous infusion of autologous mesenchymal stem cells. Clinical assessments, serum collection, and brain magnetic resonance imaging were performed at months -1, 0 (transplant), 1, 3, and 6. Matched control serum was collected once (

resultsThere were significant (

conclusionsSerum neurofilament light chain concentration correlated with magnetic resonance imaging measures of disease activity cross sectionally and longitudinally, and was stable in patients without disease activity. There was no clear treatment effect of mesenchymal stem cell transplantation on serum neurofilament light chain concentration.

Indexed as

biomarkersmesenchymal stem cellsMultiple sclerosisneurofilament light chain

Identifiers

PMID31723439
PMCPMC6831979
OpenAlexW2984818386

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.