ArticleThe journal of venomous animals and toxins including tropical diseases2019
Fibrin biopolymer as scaffold candidate to treat bone defects in rats.
Article in The journal of venomous animals and toxins including tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Autologous matrix-induced chondrogenesis is effective for focal chondral defects of the knee.Scientific reports · 2022Pooled it
- Pooled it
- Treatment of Chronic Venous Ulcers With Heterologous Fibrin Sealant: A Phase I/II Clinical Trial.Frontiers in immunology · 2021Trial
- Heterologous Fibrin Biopolymer for Post-Extraction Alveolar Bone Healing in Streptozotocin-Induced Diabetic Rats.Journal of functional biomaterials · 2026Article
- Fibrin, from blood to bone: a review.Bone reports · 2026Review
- Bone-Healing Enhancement Using Particulate Biomaterials and Fibrin-Based Compounds: A Narrative Literature Review of Evidence in Animal Models.Materials (Basel, Switzerland) · 2026Review
- Exploring bioadhesion: insight on innovative strategies to investigate bioadhesive scaffolds.International journal of pharmaceutics: X · 2025Review
- Update on synthetic biomaterials combined with fibrin derivatives for regenerative medicine: Applications in bone defect treatment: Systematic review.World journal of orthopedics · 2025Article
- Heterologous fibrin biopolymer as an emerging approach to peripheral nerve repair: a scoping review.The journal of venomous animals and toxins including tropical diseases · 2024Article
- Fibrin and Marine-Derived Agaroses for the Generation of Human Bioartificial Tissues: An Ex Vivo and In Vivo Study.Marine drugs · 2023Article
- Review
- Fixation of the Membrane during Matrix-Induced Autologous Chondrocyte Implantation in the Knee: A Systematic Review.Life (Basel, Switzerland) · 2022Review
- Physical, Mechanical, and Biological Properties of Fibrin Scaffolds for Cartilage Repair.International journal of molecular sciences · 2022Review
- Review
- Fibrin glue does not assist migration and proliferation of chondrocytes in collagenic membranes: an in vitro study.Journal of orthopaedic surgery and research · 2022Article
- Biodegradable and Biocompatible Adhesives for the Effective Stabilisation, Repair and Regeneration of Bone.Bioengineering (Basel, Switzerland) · 2022Review
- Treatment of partial injury of the calcaneus tendon with heterologous fibrin biopolymer and/or photobiomodulation in rats.Lasers in medical science · 2022Article
- A biocomplex to repair experimental critical size defects associated with photobiomodulation therapy.The journal of venomous animals and toxins including tropical diseases · 2022Article
- Comparison of Autologous Blood Clots with Fibrin Sealant as Scaffolds for Promoting Human Muscle-Derived Stem Cell-Mediated Bone Regeneration.Biomedicines · 2021Article
- Platelet-rich plasmaWorld journal of stem cells · 2021Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBone tissue repair remains a challenge in tissue engineering. Currently, new materials are being applied and often integrated with live cells and biological scaffolds. The fibrin biopolymer (FBP) proposed in this study has hemostatic, sealant, adhesive, scaffolding and drug-delivery properties. The regenerative potential of an association of FBP, biphasic calcium phosphate (BCP) and mesenchymal stem cells (MSCs) was evaluated in defects of rat femurs.
methodsAdult male Wistar rats were submitted to a 5-mm defect in the femur. This was filled with the following materials and/or associations: BPC; FBP and BCP; FBP and MSCs; and BCP, FBP and MSCs. Bone defect without filling was defined as the control group. Thirty and sixty days after the procedure, animals were euthanatized and subjected to computed tomography, scanning electron microscopy and qualitative and quantitative histological analysis.
resultsIt was shown that FBP is a suitable scaffold for bone defects due to the formation of a stable clot that facilitates the handling and optimizes the surgical procedures, allowing also cell adhesion and proliferation. The association between the materials was biocompatible. Progressive deposition of bone matrix was higher in the group treated with FBP and MSCs. Differentiation of mesenchymal stem cells into osteogenic lineage was not necessary to stimulate bone formation.
conclusionsFBP proved to be an excellent scaffold candidate for bone repair therapies due to application ease and biocompatibility with synthetic calcium-based materials. The satisfactory results obtained by the association of FBP with MSCs may provide a more effective and less costly new approach for bone tissue engineering.
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