ArticleTetrahedron2019
Iridium-Catalyzed Silylation of Unactivated C-H Bonds.
Article in Tetrahedron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Substitution, Elimination, and Integration of Methyl Groups in Terpenes Initiated by C-H Bond Functionalization.ACS central science · 2024Article
- Intermolecular C-H silylations of arenes and heteroarenes with mono-, bis-, and tris(trimethylsiloxy)hydrosilanes: control of silane redistribution under operationally diverse approaches.Chemical science · 2024Article
- Iridium-Catalyzed, Site-Selective Silylation of Secondary C(spJournal of the American Chemical Society · 2023Article
- Metathesis between E-C(spAngewandte Chemie (International ed. in English) · 2022Article
- Inorganometallics (Transition Metal-Metalloid Complexes) and Catalysis.Chemical reviews · 2022Review
- Catalytic enantioselective synthesis of benzocyclobutenols and cyclobutanolsChemical science · 2021Article
- Consecutive β,β'-Selective C(spAngewandte Chemie (International ed. in English) · 2021Article
- An asymmetric Salamo-based Zn complex supported on FeRSC advances · 2021Article
- Phosphorus(III)-assisted regioselective C-H silylation of heteroarenes.Nature communications · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The functionalization of primary C-H bonds has been a longstanding challenge in catalysis. Our group has developed a series of silylations of primary C-H bonds that occur with site selectivity and diastereoselectivity resulting from an approach to run the reactions as intramolecular processes. These reactions have become practical by using an alcohol or amine as a docking site for a hydrosilyl group, thereby leading to intramolecular silylations of C-H bonds at positions dictated by the presence common functional groups in the reactants. Oxidation of the C-Si bond leads to the introduction of alcohol functionality at the position of the primary C-H bond of the reactant. The development, scope, and applications of these functionalization reactions is described in this minireview.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.