Evidence map›Paper›PMID 31723269›Full record

ArticleNature2019

Quantifying secondary transport at single-molecule resolution.

Gabriel A Fitzgerald, Daniel S Terry, Audrey L Warren, Matthias Quick, Jonathan A Javitch, Scott C Blanchard

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 67 citations in OpenAlex.

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  15. Exploring the KeLife · 2024
    Article
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  19. Article
  20. Linking function to global and local dynamics in an elevator-type transporter.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Gabriel A Fitzgerald *Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Daniel S Terry *Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Audrey L WarrenDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Matthias QuickDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. mq2102@cumc.columbia.edu.
Jonathan A JavitchDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. jaj2@cumc.columbia.edu.
Scott C BlanchardDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. Scott.Blanchard@stjude.org.
Columbia University · USCornell University · USSt. Jude Children's Research Hospital · US

Funding

Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHOU, MING · 2010 to 2017
$31.9M
Next-generation Fluorescent Probes for Biological ResearchR01GM098859 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANCHARD, SCOTT C · 2012 to 2019
$2.9M
Probing mechanisms of amphetamine action at plasma membrane and vesicular transporters in vitro and in vivoR01DA041510 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JAVITCH, JONATHAN A · 2017 to 2021
$2.7M
Quantitative investigations of transporter dynamics and uptake at the single-moleR21MH099491 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANCHARD, SCOTT C · 2013 to 2014
$415k
Investigating Amphetamine Induced Efflux Modes in Neurotransmitter Sodium Symporters Using a Single Transporter AssayF31DA044688 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI FITZGERALD, GABRIEL ARTHUR · 2017 to 2019
$119k
NIDA NIH HHS F31 DA044688NIDA NIH HHS R01 DA041510NIGMS NIH HHS R01 GM098859NIGMS NIH HHS U54 GM087519NIH HHS F31DA044688-01NIMH NIH HHS R21 MH099491
6 · The paper itself

Abstract

Secondary active transporters, which are vital for a multitude of physiological processes, use the energy of electrochemical ion gradients to power substrate transport across cell membranes

Indexed as

Single Molecule ImagingAllosteric SiteAmino AcidsBacterial ProteinsBiological TransportCell SurvivalFluorescence Resonance Energy TransferHydrophobic and Hydrophilic InteractionsKineticsLipid BilayersProtein ConformationSymportersAmino AcidsBacterial ProteinsLipid BilayersSymporters

Identifiers

PMID31723269
PMCPMC7211416
OpenAlexW2986968588

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.