ArticleNature2019
Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease.
2 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 506 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
506citing papers in PubMed, 2 pooled it
54.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Alterations of Gut Microbiota and Metabolites in Asian Patients With Alcohol-associated Liver Disease
NCT06750588 phase1not yet recruitingnot on this mapstarted 2025, after this paper: background citation
Phase 1, Open Label Study to Evaluate Safety and Tolerability of NTR-101 in Patients With Acute Alcohol-Associated Hepatitis
Who cites it
506 citing papers in PubMed, 2 syntheses or guidelines pooled it, 794 citations in OpenAlex.
- Bacteriophage-mediated gut microbiota regulation: a bibliometric landscape analysis (2005-2024).Frontiers in microbiology · 2026Pooled it
- Influence of Alcohol on the Intestinal Immune System.Alcohol research : current reviews · 2025Pooled it
- Gut microbiota shaping fatty liver disease progression.Life science alliance · 2027Review
- Non-absorbable antibiotics worsen alcohol-associated liver disease in gastric acid-suppressed mice.Gut microbes · 2026Article
- Emerging biotechnological approaches in alcoholic liver disease: natural compounds, delivery systems, and translational potential.Science China. Life sciences · 2026Review
- Article
- Exercise as a Multisystem Adjunct for Alcohol-Associated Liver Disease: Inflammatory Mechanisms, Muscle-Liver Crosstalk, and Translational Gaps.Metabolites · 2026Review
- Decoding dysbiosis: the role of gut microbiota in MASLD progression and emerging therapeutic interventions.Journal of physiology and biochemistry · 2026Review
- Article
- Perioperative gut microbial ecology: a new frontier for improving the prognosis of hepatocellular carcinoma surgery.Precision clinical medicine · 2026Review
- MetALD Molecular Signatures: What We Know, What We Lack, and How to Move Forward Through Integrated Multi-Omics.Metabolites · 2026Review
- [Alcohol liver disease: immunoregulatory mechanisms and precision therapeutic targets].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
- Bacteriophages as Phagobiotics: Scientific Rationale and Translational Boundaries for Gut Microbiome Modulation.Viruses · 2026Review
- Gut Microbiota, Immunity, and Metabolism in the Progression From Chronic Liver Disease to Hepatocellular Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Inflammatory gut-liver crosstalk: mechanisms and therapeutic targets.Experimental & molecular medicine · 2026Review
- Impact of alcohol on gut microbial metabolism and the gut-liver-brain axis.Alcohol (Fayetteville, N.Y.) · 2026Review
- Zinc oxide-bacteriophage synergistic combination for dual-mode antibacterial activity against multidrug-resistant Escherichia coli.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Rapid detection ofMicrobiology spectrum · 2026Article
- Gut Microbiota and Ageing: A Critical Crosstalk in Alcohol-Related Liver Disease.Microorganisms · 2026Review
- Targeting tumor-associated bacteria in digestive system cancers: carcinogenic mechanisms and nano-regulate platform design.Journal of nanobiotechnology · 2026Review
446 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
46 authors at 19 institutions in 7 countries.
Yi Duan *Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Cristina Llorente *Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Sonja LangDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Katharina BrandlSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Huikuan ChuDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Lu JiangDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Richard C WhiteJ. Craig Venter Institute, Rockville, MD, USA.
Thomas H ClarkeJ. Craig Venter Institute, Rockville, MD, USA.
Kevin NguyenJ. Craig Venter Institute, Rockville, MD, USA.
Manolito TorralbaJ. Craig Venter Institute, La Jolla, CA, USA.
Yan ShaoHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Jinyuan LiuDivision of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.
Adriana Hernandez-MoralesDepartment of Biochemistry and Biophysics, Texas A & M University, College Station, TX, USA.
Lauren LessorCenter for Phage Technology, Texas A & M AgriLife Research and Texas A & M University, College Station, TX, USA.
Imran R RahmanDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Yukiko MiyamotoDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Melissa LyDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Bei GaoDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Weizhong SunDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Roman KieselDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Felix HutmacherDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Suhan LeeDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Meritxell Ventura-CotsDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh Liver Research Center, Pittsburgh, PA, USA.
Francisco Bosques-PadillaHospital Universitario, Departamento de Gastroenterología, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.
Elizabeth C VernaDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Juan G AbraldesDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Robert S BrownDivision of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY, USA.
Victor VargasLiver Unit, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Jose AltamiranoLiver Unit, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Juan CaballeríaCentro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Barcelona, Spain.
Debbie L ShawcrossLiver Sciences, Department of Inflammation Biology, School of Infectious Diseases and Microbial Sciences, King's College London, London, UK.
Samuel B HoDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Alexandre LouvetService des Maladies de L'appareil Digestif et Unité INSERM, Hôpital Huriez, Lille, France.
Michael R LuceyDivision of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Philippe MathurinService des Maladies de L'appareil Digestif et Unité INSERM, Hôpital Huriez, Lille, France.
Guadalupe Garcia-TsaoSection of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.
Ramon BatallerDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh Liver Research Center, Pittsburgh, PA, USA.
Xin M TuDivision of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.
Lars EckmannDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Wilfred A van der DonkDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Ry YoungDepartment of Biochemistry and Biophysics, Texas A & M University, College Station, TX, USA.
Trevor D LawleyHost-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Peter StärkelSt Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
David PrideDepartment of Medicine, University of California San Diego, La Jolla, CA, USA.
Derrick E FoutsJ. Craig Venter Institute, Rockville, MD, USA.
Bernd SchnablDepartment of Medicine, University of California San Diego, La Jolla, CA, USA. beschnabl@ucsd.edu.
University of California, San Diego · USJ. Craig Venter Institute · USTexas A&M University · USInserm · FRUniversitat Autònoma de Barcelona · ESUniversity of Pittsburgh Medical Center · USVA San Diego Healthcare System · USWellcome Sanger Institute · GBCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESColumbia University · USCornell University · USHoward Hughes Medical Institute · USKing's College London · GBUCLouvain · BEUniversidad Autónoma de Nuevo León · MXUniversity of Alberta · CAUniversity of Illinois Urbana-Champaign · USUniversity of Wisconsin–Madison · USVA Connecticut Healthcare System · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MThe Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8MYale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI YASUKO IWAKIRI · 1986 to 2026
$31.1MPittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVID A GELLER · 2019 to 2026
$10.9MSan Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8MMolecular Subtypes for Targeted Therapies in Alcoholic HepatitisU01AA021908 · NIAAA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BATALLER, RAMON · 2013 to 2017
$6.0MTraining Program in Chemistry-Interface with BiologyT32GM070421 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL · 2005 to 2019
$5.4MThe Role of the Intestinal Mycobiome in Alcoholic Liver DiseaseR01AA024726 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2018 to 2026
$3.9MMicrobiome and intestinal innate immune response in alcoholic liver diseaseR01AA020703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHNABL, BERND G. · 2011 to 2020
$3.6MMicrobiome as therapeutic target in alcoholic hepatitisU01AA026939 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FOUTS, DERRICK E, SCHNABL, BERND G. · 2018 to 2022
$1.7MThe role of pathobionts in alcoholic liver diseaseI01BX004594 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI Bernd G. Schnabl · 2019 to 2026
–BLRD VA I01 BX004594NCATS NIH HHS UL1 TR001863NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R01 AA020703NIAAA NIH HHS R01 AA024726NIAAA NIH HHS U01 AA021908NIAAA NIH HHS U01 AA026939NIDDK NIH HHS P30 DK034989NIDDK NIH HHS P30 DK120515NIDDK NIH HHS P30 DK120531NIGMS NIH HHS T32 GM070421Wellcome Trust 093869
Abstract
Chronic liver disease due to alcohol-use disorder contributes markedly to the global burden of disease and mortality
Indexed as
Gastrointestinal MicrobiomePhage TherapyAlcoholismAnimalsBacteriophagesEnterococcus faecalisEthanolFatty LiverFecesFemaleGerm-Free LifeHepatitis, AlcoholicHepatocytesHumansLiverMaleEthanolPerforin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT05448144ClinicalTrials.gov
NCT06750588ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.