Evidence map›Paper›PMID 31723237›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2020

Characteristics and short-term outcomes of neonates with mild hypoxic-ischemic encephalopathy treated with hypothermia.

Ipsita R Goswami, Hilary Whyte, Pia Wintermark, Khorshid Mohammad, Sandesh Shivananda, Deepak Louis, Eugene W Yoon, Prakesh S Shah, Canadian Neonatal Network Investigators

Registry-linked trialAbstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06985290 (Comparative Efficacy of Dexmedetomidine Versus Morphine in Alleviating Secondary Brain Injury, When Used for Sedation During Hypothermia Therapy in Neonates), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06985290 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Comparative Efficacy of Dexmedetomidine Versus Morphine in Alleviating Secondary Brain Injury, When Used for Sedation During Hypothermia Therapy in Neonates: A Pilot Randomized Trial

TypeinterventionalSponsorIpsita GoswamiRan2025 to 2028Enrolled50ConditionsHypoxic Ischemic Brain Injury, Neonatal Encephalopathy, Perinatal Anoxic-ischemic Brain InjuryArmsDexmedetomidine Infusion, Morphine Infusion
3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  19. Brain injury following mild hypoxic-ischemic encephalopathy in neonates-Ten-year experience in a tertiary perinatal center.Journal of perinatology : official journal of the California Perinatal Association · 2022
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  20. Outcomes of infants with hypoxic-ischemic encephalopathy during COVID-19 pandemic lockdown in Canada: a cohort study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ipsita R GoswamiDepartment of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Hilary WhyteDepartment of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Pia WintermarkDepartment of Pediatrics, McGill University, Montreal, QC, Canada.
Khorshid MohammadDepartment of Pediatrics, University of Calgary, Calgary, AB, Canada.
Sandesh ShivanandaDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Deepak LouisDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
Eugene W YoonMaternal-infant Care Research Centre, Mount Sinai Hospital, Toronto, ON, Canada.
Prakesh S ShahMaternal-infant Care Research Centre, Mount Sinai Hospital, Toronto, ON, Canada. Prakeshkumar.Shah@sinaihealthsystem.ca.ORCID http://orcid.org/0000-0002-9920-0488
Canadian Neonatal Network Investigators

Funding

CIHR APR-126340CIHR CTP 87518
6 · The paper itself

Abstract

objectiveTo compare the characteristics and outcomes of neonates with mild hypoxic-ischemic encephalopathy (HIE) who received hypothermia versus standard care. STUDY

designWe conducted a retrospective cohort study of neonates ≥35 weeks' gestation and ≥1800 g admitted with a diagnosis of Sarnat stage 1 encephalopathy. We evaluated length of hospital stay, duration of ventilation, evidence of brain injury on MRI, and neonatal morbidities.

resultsOf 1089 eligible neonates, 393 (36%) received hypothermia and 595 (55%) had neuroimaging. The hypothermia group was more likely to be outborn, born via C-section, had lower Apgar scores, and required extensive resuscitation. They had longer durations of stay (9 vs. 6 days, P < 0.001), respiratory support (3 vs. 2 days, P < 0.001), but lower odds of brain injury on MRI (adjusted odds ratio 0.33, 95% CI: 0.22-0.52) compared with standard care group.

conclusionDespite prolongation of hospital stay, hypothermia may be potentially beneficial in neonates with mild HIE; however, selection bias cannot be ruled out.

Indexed as

Hypothermia, InducedBrainBrain InjuriesCanadaFemaleHumansHypoxia-Ischemia, BrainInfant, NewbornLength of StayMagnetic Resonance ImagingMaleNeuroimagingPatient AcuityRespiration, ArtificialRetrospective StudiesSelection Bias

Identifiers

PMID31723237

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.