ArticleScientific reports2019
Bioactive coating of zirconia toughened alumina ceramic implants improves cancellous osseointegration.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 61 citations in OpenAlex.
- Hydrolytically Stable Organo-Chemical Surface Functionalization of Bioinert High-Performance Ceramics Enables Osseoconduction and Osseointegration In Vivo.Journal of functional biomaterials · 2026Article
- Computational analysis of L4-L5 interspinous process devices and interbody fusion spacers using ceramic and polymeric materials via finite element modeling and artificial intelligence.Scientific reports · 2025Article
- Fabrication and Evaluation of Ceramic-Based Hollow Fiber Membrane Modules for Hemodialysis Applications.Membranes · 2025Article
- Osteointegration of functionalised high-performance oxide ceramics: imaging from micro-computed tomography.Journal of orthopaedic surgery and research · 2024Article
- Comparative Analysis of Bone Ingrowth in 3D-Printed Titanium Lattice Structures with Different Patterns.Materials (Basel, Switzerland) · 2023Article
- Ceramic Materials for Biomedical Applications: An Overview on Properties and Fabrication Processes.Journal of functional biomaterials · 2023Review
- Silica coated high performance oxide ceramics promote greater ossification than titanium implants: an in vivo study.Journal of orthopaedic surgery and research · 2023Article
- Bioactive Inorganic Materials for Dental Applications: A Narrative Review.Materials (Basel, Switzerland) · 2022Review
- DLP Fabrication of Zirconia Scaffolds Coated with HA/β-TCP Layer: Role of Scaffold Architecture on Mechanical and Biological Properties.Journal of functional biomaterials · 2022Article
- Oral Tissue Interactions and Cellular Response to Zirconia Implant-Prosthetic Components: A Critical Review.Materials (Basel, Switzerland) · 2021Review
- Osseointegration of a novel dental implant in canine.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioactive coatings have the potential to improve the bony integration of mechanically loaded orthopedic ceramic implants. Using the concept of mimicking the natural bone surface, four different coatings of varying thickness on a zirconia toughened alumina (ZTA) ceramic implant were investigated regarding their osseointegration in a drill-hole model in sheep. The hypothesis that a bioactive coating of ZTA ceramics would facilitate cancellous bone integration was investigated. The bioactive coatings consisted of either a layer of covalently bound multi phosphonate molecules (chemical modification = CM), a nano hydoxyapatite coating (HA), or two different bioactive glass (BG) coatings in micrometer thickness, forming a hydroxyl-carbonate apatite layer on the implant surface in vivo (dip-coated 45S5 = DipBG; sol-gel 70S30C = SGBG). Coated surfaces were characterized by scanning electron microscopy and X-ray photoelectron spectroscopy. After 12 weeks, osseointegration was evaluated via mechanical push-out testing and histology. HA enhanced the maximum push-out force (HA: mean 3573.85 ± 1119.91 N; SGBG: mean 1691.57 ± 986.76 N; p = 0.046), adhesive shear strength (HA: mean 9.82 ± 2.89 MPA; SGBG: mean 4.57 ± 2.65 MPA; p = 0.025), and energy release rate (HA: mean 3821.95 ± 1474.13 J/mm
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