Trial reportJCI insight2019
Continuous vestibular implant stimulation partially restores eye-stabilizing reflexes.
Trial report in JCI insight, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
First-in-Human Early Feasibility Study of Safety, Tolerability and Efficacy for a Multichannel Vestibular Implant in Individuals With Bilateral Severe-to-Profound Loss of Vestibular Sensation
Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction
Vestibular Implantation in Older Adults
Long Term Outcomes After Vestibular Implantation
Vestibular Implant Tested in Patients With Peripheral Vestibular Damage: Effects on Spatial Orientation, Navigation, and Neuropsychologic Function
Who cites it
36 citing papers in PubMed, 76 citations in OpenAlex.
- Rapid acclimatization to baseline stimulation with a multi-canal vestibulocochlear implant.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Trial
- Posture, Gait, Quality of Life, and Hearing with a Vestibular Implant.The New England journal of medicine · 2021Trial
- Vestibular Implant Imaging.AJNR. American journal of neuroradiology · 2021Trial
- Vestibulocochlear implant (VCI) modulation improves mid and high frequency vestibulo-ocular reflex (VOR).Journal of neurology · 2026Article
- Effects of Electrode Position on Vestibular Implant Performance in Rhesus Macaque.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Article
- Vestibular implant stimulation can improve self-motion perception.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Exploring the role of the electrically evoked Vestibulo-Ocular reflex in vestibular implant surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Perceptual response characterization in acute vestibular implant stimulation.Journal of neurology · 2025Article
- Enhancing balance and auditory function in bilateral vestibulopathy through otolithic vestibular stimulation: insights from a pilot study on cochlea-vestibular implant efficacy.Frontiers in neurology · 2025Article
- Review
- Pulsatile electrical stimulation creates predictable, correctable disruptions in neural firing.Nature communications · 2024Article
- Vestibular Implant Surgery.The Laryngoscope · 2024Article
- The vestibular implant: effects of stimulation parameters on the electrically-evoked vestibulo-ocular reflex.Frontiers in neurology · 2024Article
- Article
- Binocular 3-D otolith-ocular reflexes: responses of chinchillas to natural and prosthetic stimulation after ototoxic injury and vestibular implantation.Journal of neurophysiology · 2023Article
- Vestibular prosthesis: from basic research to clinics.Frontiers in integrative neuroscience · 2023Review
- Computer Simulation of the Electrical Stimulation of the Human Vestibular System: Effects of the Reactive Component of Impedance on Voltage Waveform and Nerve Selectivity.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- The resilience of the inner ear-vestibular and audiometric impact of transmastoid semicircular canal plugging.Journal of neurology · 2022Article
- A prosthesis utilizing natural vestibular encoding strategies improves sensorimotor performance in monkeys.PLoS biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUNDBilateral loss of vestibular (inner ear inertial) sensation causes chronically blurred vision during head movement, postural instability, and increased fall risk. Individuals who fail to compensate despite rehabilitation therapy have no adequate treatment options. Analogous to hearing restoration via cochlear implants, prosthetic electrical stimulation of vestibular nerve branches to encode head motion has garnered interest as a potential treatment, but prior studies in humans have not included continuous long-term stimulation or 3D binocular vestibulo-ocular reflex (VOR) oculography, without which one cannot determine whether an implant selectively stimulates the implanted ear's 3 semicircular canals.METHODSWe report binocular 3D VOR responses of 4 human subjects with ototoxic bilateral vestibular loss unilaterally implanted with a Labyrinth Devices Multichannel Vestibular Implant System vestibular implant, which provides continuous, long-term, motion-modulated prosthetic stimulation via electrodes in 3 semicircular canals.RESULTSInitiation of prosthetic stimulation evoked nystagmus that decayed within 30 minutes. Stimulation targeting 1 canal produced 3D VOR responses approximately aligned with that canal's anatomic axis. Targeting multiple canals yielded responses aligned with a vector sum of individual responses. Over 350-812 days of continuous 24 h/d use, modulated electrical stimulation produced stable VOR responses that grew with stimulus intensity and aligned approximately with any specified 3D head rotation axis.CONCLUSIONThese results demonstrate that a vestibular implant can selectively, continuously, and chronically provide artificial sensory input to all 3 implanted semicircular canals in individuals disabled by bilateral vestibular loss, driving reflexive VOR eye movements that approximately align in 3D with the head motion axis encoded by the implant.TRIAL REGISTRATIONClinicalTrials.gov: NCT02725463.FUNDINGNIH/National Institute on Deafness and Other Communication Disorders: R01DC013536 and 2T32DC000023; Labyrinth Devices, LLC; and Med-El GmbH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.