ArticleProceedings of the National Academy of Sciences of the United States of America2019
Real-time probing of chirality during a chemical reaction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Quantum-elevated chiral discrimination for biomolecules.Science advances · 2026Article
- Symmetries and selection rules in photoelectron chiral dichroism.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Ultrafast spectroscopy of liquids using extreme-ultraviolet to soft-X-ray pulses.Nature reviews. Chemistry · 2025Review
- Time-Resolved Circular Dichroism in Molecules: Experimental and Theoretical Advances.Molecules (Basel, Switzerland) · 2024Review
- Giant ultrafast dichroism and birefringence with active nonlocal metasurfaces.Light, science & applications · 2024Article
- Manipulating ultrafast even-order nonlinear chiral responses of L-tryptophan by polarization pulse shaping.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Modeling of High-Harmonic Generation in the CThe journal of physical chemistry. A · 2024Article
- High-harmonic spectroscopy of impulsively aligned 1,3-cyclohexadiene: Signatures of attosecond charge migration.Structural dynamics (Melville, N.Y.) · 2024Article
- Tunable Tesla-Scale Magnetic Attosecond Pulses through Ring-Current Gating.The journal of physical chemistry letters · 2023Article
- Theoretical study of time-resolved photoelectron circular dichroism in the photodissociation of a chiral molecule.Structural dynamics (Melville, N.Y.) · 2023Article
- Time-resolved enantiomer-exchange probed by using the orbital angular momentum of X-ray light.Chemical science · 2023Article
- Time-resolved circular dichroism of excitonic systems: theory and experiment on an exemplary squaraine polymer.Chemical science · 2023Article
- Ground-State Photoelectron Circular Dichroism of Methyl p-Tolyl Sulfoxide by Single-Photon Ionisation from a Table-Top Source.Chemphyschem : a European journal of chemical physics and physical chemistry · 2022Article
- Pump-probe spectroscopy of chiral vibrational dynamics.Science advances · 2022Article
- Ultrafast chirality: the road to efficient chiral measurements.Physical chemistry chemical physics : PCCP · 2022Review
- Perspectives on parity violation in chiral molecules: theory, spectroscopic experiment and biomolecular homochirality.Chemical science · 2022Review
- Femtosecond photoelectron circular dichroism of chemical reactions.Science advances · 2022Article
- Necklace-structured high-harmonic generation for low-divergence, soft x-ray harmonic combs with tunable line spacing.Science advances · 2022Article
- Site-specific interrogation of an ionic chiral fragment during photolysis using an X-ray free-electron laser.Communications chemistry · 2021Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chiral molecules interact and react differently with other chiral objects, depending on their handedness. Therefore, it is essential to understand and ultimately control the evolution of molecular chirality during chemical reactions. Although highly sophisticated techniques for the controlled synthesis of chiral molecules have been developed, the observation of chirality on the natural femtosecond time scale of a chemical reaction has so far remained out of reach in the gas phase. Here, we demonstrate a general experimental technique, based on high-harmonic generation in tailored laser fields, and apply it to probe the time evolution of molecular chirality during the photodissociation of 2-iodobutane. These measurements show a change in sign and a pronounced increase in the magnitude of the chiral response over the first 100 fs, followed by its decay within less than 500 fs, revealing the photodissociation to achiral products. The observed time evolution is explained in terms of the variation of the electric and magnetic transition-dipole moments between the lowest electronic states of the cation as a function of the reaction coordinate. These results open the path to investigations of the chirality of molecular-reaction pathways, light-induced chirality in chemical processes, and the control of molecular chirality through tailored laser pulses.
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