Evidence map›Paper›PMID 31723042›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Dysregulation of different classes of tRNA fragments in chronic lymphocytic leukemia.

Dario Veneziano, Luisa Tomasello, Veronica Balatti, Alexey Palamarchuk, Laura Z Rassenti, Thomas J Kipps, Yuri Pekarsky, Carlo M Croce

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
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  3. Article
  4. The Roles of tRNA-Derived Fragments in Cancer: Updates and Perspectives.International journal of molecular sciences · 2025
    Review
  5. Overview of the Different Classes of Small RNAs During B-Cell Development.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
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  18. tRNA-derived fragments (tRFs) in cancer.Journal of cell communication and signaling · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dario VenezianoDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210.
Luisa TomaselloDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210.
Veronica BalattiDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210.
Alexey PalamarchukDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210.
Laura Z RassentiDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.
Thomas J KippsDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.
Yuri PekarskyDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210; pekarsky.yuri@osumc.edu carlo.croce@osumc.edu.
Carlo M CroceDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, OH 43210; pekarsky.yuri@osumc.edu carlo.croce@osumc.edu.
The Ohio State University · USUniversity of California, San Diego · US

Funding

Tissue CoreP01CA081534 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KIPPS, THOMAS J · 2000 to 2016
$59.5M
Cancer Gene Discovery to Identify Targetable TargetsR35CA197706 · NCI · OHIO STATE UNIVERSITY · PI CROCE, CARLO M · 2015 to 2021
$6.4M
NCI NIH HHS P01 CA081534NCI NIH HHS R35 CA197706
6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is the most common human leukemia, and dysregulation of tRNA-derived short noncoding RNA (tsRNA) (tRF-1) expression is an accompanying event in the development of this disease. tsRNAs are fragments originating from the 3' end of tRNA precursors and do not contain mature tRNA sequences. In contrast to tsRNAs, mature tRFs (tRF-3s, tRF-5s, and internal tRFs) are produced from mature tRNA sequences and are redundant fragments. We investigated tsRNA expression in CLL and determined tsRNA signatures in indolent CLL and aggressive CLL vs. normal B cells. We noticed that both

Indexed as

Gene Expression Regulation, LeukemicCase-Control StudiesDNA MethylationDown-RegulationHumansLeukemia, Lymphocytic, Chronic, B-CellRNA PrecursorsRNA, Small UntranslatedRNA, TransferRNA, Transfer, HisRNA PrecursorsRNA, Small UntranslatedRNA, TransferRNA, Transfer, HistRFstRNA fragmentstsRNAs

Identifiers

PMID31723042
PMCPMC6883801
OpenAlexW2983574209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.