Evidence map›Paper›PMID 31723032›Full record

ArticleThe Journal of biological chemistry2019

Endoplasmic reticulum stress differentially inhibits endoplasmic reticulum and inner nuclear membrane protein quality control degradation pathways.

Bryce W Buchanan, Adrian B Mehrtash, Courtney L Broshar, Avery M Runnebohm, Brian J Snow, Laura N Scanameo, Mark Hochstrasser, Eric M Rubenstein

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bryce W BuchananDepartment of Biology, Ball State University, Muncie, Indiana 47306.
Adrian B MehrtashDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520.
Courtney L BrosharDepartment of Biology, Ball State University, Muncie, Indiana 47306.
Avery M RunnebohmDepartment of Biology, Ball State University, Muncie, Indiana 47306.
Brian J SnowDepartment of Biology, Ball State University, Muncie, Indiana 47306.
Laura N ScanameoDepartment of Biology, Ball State University, Muncie, Indiana 47306.
Mark HochstrasserDepartment of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520.ORCID 0000-0002-1131-5484
Eric M RubensteinDepartment of Biology, Ball State University, Muncie, Indiana 47306 emrubenstein@bsu.edu.ORCID 0000-0003-4983-1430
Ball State University · USYale University · US

Funding

Degradation of Short Lived Regulatory Protein in YeastR37GM046904 · NIGMS · YALE UNIVERSITY · PI HOCHSTRASSER, MARK W · 2009 to 2018
$3.6M
DEGRADTION OF SHORT-LIVED REGULATORY PROTEINS IN YEASTR01GM046904 · NIGMS · YALE UNIVERSITY · PI HOCHSTRASSER, MARK W · 1992 to 2020
$3.6M
Regulation of Endoplasmic Reticulum Protein Quality Control by Microtubule-Associated ProteinsR15GM111713 · NIGMS · BALL STATE UNIVERSITY · PI Eric Meyer Rubenstein · 2014 to 2026
$1.8M
NIGMS NIH HHS R01 GM046904NIGMS NIH HHS R15 GM111713NIGMS NIH HHS R37 GM046904
6 · The paper itself

Abstract

Endoplasmic reticulum (ER) stress occurs when the abundance of unfolded proteins in the ER exceeds the capacity of the folding machinery. Despite the expanding cadre of characterized cellular adaptations to ER stress, knowledge of the effects of ER stress on cellular physiology remains incomplete. We investigated the impact of ER stress on ER and inner nuclear membrane protein quality control mechanisms in

Indexed as

Endoplasmic Reticulum StressAnimalsCattleCell NucleusEndoplasmic ReticulumGene Expression Regulation, FungalMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseMembrane ProteinsMembrane Transport ProteinsMetalloendopeptidasesNuclear EnvelopePhosphoric Monoester HydrolasesPlasmidsProtein TransportProtein UnfoldingProteolysisHRD1 protein, S cerevisiaeMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseMembrane ProteinsMembrane Transport ProteinsMetalloendopeptidasesPhosphoric Monoester HydrolasesRkr1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsSEC62 protein, S cerevisiaeSSM4 protein, S cerevisiaeSTE24 protein, S cerevisiaeUbiquitin-Protein LigasesE3 ubiquitin ligaseendoplasmic reticulum–associated protein degradation (ERAD)endoplasmic reticulum stress (ER stress)inner nuclear membrane-associated degradation (INMAD)protein quality controlprotein translocationSaccharomyces cerevisiaeSte24transloconyeast genetics

Identifiers

PMID31723032
PMCPMC6926463
OpenAlexW2983838787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.