Evidence map›Paper›PMID 31723031›Full record

ArticleThe Journal of biological chemistry2019

Glucocorticoids potentiate the inhibitory capacity of programmed cell death 1 by up-regulating its expression on T cells.

Natsumi Maeda, Takumi Maruhashi, Daisuke Sugiura, Kenji Shimizu, Il-Mi Okazaki, Taku Okazaki

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Local Effects of Steroid Hormones within the Bone Microenvironment.International journal of molecular sciences · 2023
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Natsumi MaedaDivision of Immune Regulation, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.
Takumi MaruhashiDivision of Immune Regulation, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.ORCID 0000-0003-2944-1611
Daisuke SugiuraDivision of Immune Regulation, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.ORCID 0000-0002-3865-3889
Kenji ShimizuDivision of Immune Regulation, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.
Il-Mi OkazakiDivision of Immune Regulation, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.ORCID 0000-0001-8644-0100
Taku OkazakiDivision of Immune Regulation, Institute of Advanced Medical Sciences, Tokushima University, 3-18-15 Kuramoto, Tokushima 770-8503, Japan tokazaki@iam.u-tokyo.ac.jp.ORCID 0000-0003-4790-1925
The University of Tokyo · JPTokushima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inhibitory co-receptor programmed cell death 1 (PD-1,

Indexed as

AnimalsAnti-Inflammatory AgentsCD8-Positive T-LymphocytesCells, CulturedDexamethasoneGlucocorticoidsMiceMice, Inbred BALB CMice, Inbred C57BLProgrammed Cell Death 1 ReceptorPromoter Regions, GeneticReceptors, GlucocorticoidT-LymphocytesTranscriptional ActivationTranscription Initiation SiteUp-RegulationAnti-Inflammatory AgentsDexamethasoneGlucocorticoidsPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorReceptors, Glucocorticoidcoreceptorcytokine inductiongene expressionglucocorticoidimmune checkpointimmunologyimmunosuppressionPD-1T cellT cell receptor (TCR)

Identifiers

PMID31723031
PMCPMC6937557
OpenAlexW2987531259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.