ArticleJournal of virology2020
Impact of Antiretroviral Therapy Duration on HIV-1 Infection of T Cells within Anatomic Sites.
Open access · hybridAbstract read
In one paragraph
Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- The impacts of tobacco and nicotine on HIV-1 infection, inflammation, and the blood-brain barrier in the central nervous system.Frontiers in pharmacology · 2024Review
- HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model.Journal of virology · 2023Article
- Unequal distribution of genetically-intact HIV-1 proviruses in cells expressing the immune checkpoint markers PD-1 and/or CTLA-4.Frontiers in immunology · 2023Article
- Plasma-Derived HIV-1 Virions Contain Considerable Levels of Defective Genomes.Journal of virology · 2022Article
- Long-term immunologic effects of SARS-CoV-2 infection: leveraging translational research methodology to address emerging questions.Translational research : the journal of laboratory and clinical medicine · 2022Review
- Measuring Proviral HIV-1 DNA: Hurdles and Improvements to an Assay Monitoring Integration Events Utilising HumanLife (Basel, Switzerland) · 2021Article
- HIV-1 viral blips are associated with repeated and increasingly high levels of cell-associated HIV-1 RNA transcriptional activity.AIDS (London, England) · 2021Article
- HIV-1 Genomes Are Enriched in Memory CD4mBio · 2021Article
- Human Immunodeficiency Virus Persistence in the Spleen: Opportunities for Pharmacologic Intervention.AIDS research and human retroviruses · 2021Article
- Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART.PLoS pathogens · 2021Article
- Article
- Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype.PLoS pathogens · 2021Article
- Subclinical Genital Herpes Shedding in HIV/Herpes Simplex Virus 2-Coinfected Women during Antiretroviral Therapy Is Associated with an Increase in HIV Tissue Reservoirs and Potentially Promotes HIV Evolution.Journal of virology · 2020Article
- Article
- Boosting the Immune System for HIV Cure: A γδ T Cell Perspective.Frontiers in cellular and infection microbiology · 2020Review
- Morphine exposure exacerbates HIV-1 Tat driven changes to neuroinflammatory factors in cultured astrocytes.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 8 institutions in 4 countries.
Eunok LeeThe Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia eunok.lee@sydney.edu.au.
Susanne von StockenstromDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Vincent MorcillaThe Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia.
Lina OdevallDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Bonnie HienerThe Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia.
Wei ShaoAdvanced Biomedical Computing Center, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Wendy HartogensisDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Peter BacchettiDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Jeffrey MilushDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Teri LieglerDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Elizabeth SinclairDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Hiroyu HatanoDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Rebecca HohDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Ma SomsoukDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Peter HuntDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Eli BoritzHuman Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Daniel DouekHuman Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Remi FromentinCentre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Canada.
Nicolas ChomontCentre de Recherche du CHUM and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, Canada.
Steven G DeeksDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Frederick M HechtDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Sarah PalmerThe Westmead Institute for Medical Research, University of Sydney, Westmead, New South Wales, Australia.
University of California, San Francisco · USCentre Hospitalier de l’Université de Montréal · CANational Institute of Allergy and Infectious Diseases · USUniversity of Sydney · AUWestmead Institute for Medical Research · AUFrederick National Laboratory for Cancer Research · USKarolinska Institutet · SEKarolinska University Hospital · SE
Funding
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6MViral reservoirs and sanctuaries in HAART - treated patients: role and mechanismsU19AI096109 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PALMER, SARAH ELIZABETH · 2011 to 2015
$29.5MDelaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9MTiming of ART and homeostasis of the persistent HIV reservoir in the adultR01AI116368 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, PETER W · 2015 to 2019
$3.7MPersistent Functional Immune Defects in Treated HIV InfectionK24AI145806 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, PETER W · 2020 to 2024
$921kNIAID NIH HHS K24 AI145806NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI116368NIAID NIH HHS U19 AI096109NIAID NIH HHS UM1 AI126611
Abstract
Understanding the impact of antiretroviral therapy (ART) duration on HIV-infected cells is critical for developing successful curative strategies. To address this issue, we conducted a cross-sectional/inter-participant genetic characterization of HIV-1 RNA from pre- and on-therapy plasmas and HIV-1 DNA from CD4
Indexed as
Duration of TherapyAdolescentAnti-Retroviral AgentsCD4-Positive T-LymphocytesChildChild, PreschoolCross-Sectional StudiesDNA, ViralHIV-1HIV InfectionsHumansLymph NodesProvirusesT-Lymphocyte SubsetsViral LoadViremiaAnti-Retroviral AgentsDNA, Viralacute/early infectionanatomic sitesCD4+ T cell subsetscellular proliferationchronic infectionHIV-1HIV-1 persistencelong-term antiretroviral therapysingle-genome sequencingsingle-proviral sequencing
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.