Evidence map›Paper›PMID 31723011›Full record

ArticleJournal of clinical microbiology2020

Diagnostic Value of Detection of Pregenomic RNA in Sera of Hepatitis B Virus-Infected Patients with Different Clinical Outcomes.

Ni Lin, Aizhu Ye, Jinpiao Lin, Can Liu, Jinlan Huang, Ya Fu, Songhang Wu, Siyi Xu, Long Wang, Qishui Ou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  6. Elevated Hepatitis B virus RNA levels in hepatocellular carcinoma patients compared to cirrhotic individuals: A propensity score matched analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024
    Article
  7. [Serum hepatitis B virus pregenomic RNA profiles in patients with chronic hepatitis B on long-term antiviral therapy].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ni Lin *First Clinical College, Fujian Medical University, Fuzhou, China.
Aizhu Ye *First Clinical College, Fujian Medical University, Fuzhou, China.
Jinpiao LinFirst Clinical College, Fujian Medical University, Fuzhou, China.
Can LiuFirst Clinical College, Fujian Medical University, Fuzhou, China.
Jinlan HuangFirst Clinical College, Fujian Medical University, Fuzhou, China.
Ya FuFirst Clinical College, Fujian Medical University, Fuzhou, China.
Songhang WuFirst Clinical College, Fujian Medical University, Fuzhou, China.
Siyi XuFirst Clinical College, Fujian Medical University, Fuzhou, China.
Long WangFirst Clinical College, Fujian Medical University, Fuzhou, China.
Qishui OuFirst Clinical College, Fujian Medical University, Fuzhou, China ouqishui@fjmu.edu.cn.
First Affiliated Hospital of Fujian Medical University · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregenomic RNA (pgRNA) is a direct transcription product of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA), and it plays important roles in viral genome amplification and replication. This study was designed to investigate whether serum pgRNA is a strong alternative marker for reflecting HBV cccDNA levels and to analyze the correlation between serum pgRNA, serum HBV DNA, and hepatitis B surface antigen (HBsAg). A total of 400 HBV-infected patients who received nucleos(t)ide analog (NA) therapy with different clinical outcomes were involved in this research. Case groups included asymptomatic hepatitis B virus carrier (ASC), chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC) patients, with 100 patients in each group. The results showed that the levels of HBV pgRNA had significant differences between these 4 groups. Serum pgRNA levels correlated well with serum HBV DNA and HBsAg levels (HBV pgRNA levels versus HBV DNA levels,

Indexed as

AdultAgedAntiviral AgentsBiomarkersCarcinoma, HepatocellularCarrier StateDNA, CircularFemaleHepatitis BHepatitis B e AntigensHepatitis B Surface AntigensHepatitis B virusHumansLiverLiver NeoplasmsMaleAntiviral AgentsBiomarkersDNA, CircularHepatitis B e AntigensHepatitis B Surface AntigensRNA, Viralclinical outcomescovalently closed circular DNAhepatitis B viruspregenomic RNAreal-time fluorescence quantitative PCR

Identifiers

PMID31723011
PMCPMC6989074
OpenAlexW2985772889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.