Evidence map›Paper›PMID 31723001›Full record

ArticleCancer research2020

Association of Genomic Domains in

Vivek L Patel, Evan L Busch, Tara M Friebel, Angel Cronin, Goska Leslie, Lesley McGuffog, Julian Adlard, Simona Agata, Bjarni A Agnarsson, Munaza Ahmed and 253 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Ovarian Cancer: Multi-Omics Data Integration.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Review
  9. BRCA Mutations and Fertility Preservation.International journal of molecular sciences · 2023
    Review
  10. CanRisk-Prostate: A Comprehensive, Externally Validated Risk Model for the Prediction of Future Prostate Cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Analysis ofFrontiers in oncology · 2022
    Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

263 authors at 20 institutions in 31 countries.

Vivek L PatelDepartment of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts.
Evan L BuschHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
Tara M FriebelHarvard T.H. Chan School of Public Health, Boston, Massachusetts.
Angel CroninDana-Farber Cancer Institute. Boston, Massachusetts.
Goska LeslieCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-5756-6222
Lesley McGuffogCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Julian AdlardYorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom.ORCID 0000-0002-1693-0435
Simona AgataImmunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Bjarni A AgnarssonDepartment of Pathology, Landspitali University Hospital, 101, Reykjavik, Iceland.
Munaza AhmedNorth East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
Kristiina AittomäkiDepartment of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Elisa AlducciImmunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Irene L AndrulisFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Adalgeir ArasonDepartment of Pathology, Landspitali University Hospital, 101, Reykjavik, Iceland.
Norbert ArnoldDepartment of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany.ORCID 0000-0003-4523-8808
Grazia ArtioliULSS 3 Serenissima, U.O.C. Oncologia ed Ematologia Oncologica, Mirano, Venice, Italy.
Brita ArverDepartment of Oncology, Karolinska Institutet, Stockholm, Sweden.
Bernd AuberInstitute of Human Genetics, Hannover Medical School, Hannover, Germany.ORCID 0000-0003-1880-291X
Jacopo AzzolliniUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy.ORCID 0000-0002-9364-9778
Judith BalmañaHigh Risk and Cancer Prevention Group, Vall d'Hebron Institute of Oncology, University Hospital Vall d'Hebron, Barcelona, Spain.
Rosa B BarkardottirDepartment of Pathology, Landspitali University Hospital, 101, Reykjavik, Iceland.
Daniel R BarnesCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-3781-7570
Alicia BarrosoHuman Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Daniel BarrowdaleCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Muriel BelottiService de Génétique, Institut Curie, Paris, France.
Javier BenitezHuman Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Birgitte BertelsenCenter for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Marinus J BlokDepartment of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands.
Istvan BodrogiDepartment of Chemotherapy, National Institute of Oncology, Budapest, Hungary.
Valérie BonadonaUnité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.
Bernardo BonanniDivision of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Davide BondavalliDivision of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Susanne E BoonenClinical Genetic Unit, Department of Paediatrics, Zealand University Hospital, Roskilde, Denmark.
Julika BordeCenter for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
Ake BorgDepartment of Oncology, Lund University and Skåne University Hospital, Lund, Sweden.
Angela R BradburyDepartment of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Angela BradyNorth West Thames Regional Genetics Service, Kennedy Galton Centre, The North West London Hospitals NHS Trust, Middlesex, United Kingdom.
Carole BrewerDepartment of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom.
Joan BrunetGenetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain.ORCID 0000-0003-1945-3512
Bruno BuecherService de Génétique, Institut Curie, Paris, France.
Saundra S BuysDepartment of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah.
Santiago Cabezas-CamareroDepartment of Oncology, Hospital Clinico San Carlos, IdISSC, Madrid, Spain.
Trinidad CaldésMedical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Almuth CaliebeInstitute of Human Genetics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany.
Maria A CaligoSection of Molecular Genetics, Department of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy.ORCID 0000-0003-0589-1829
Mariarosaria CalvelloDivision of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Ian G CampbellPeter MacCallum Cancer Center, Melbourne, Victoria, Australia.ORCID 0000-0002-7773-4155
Ileana CarnevaliUO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, Italy.
Estela CarrascoHigh Risk and Cancer Prevention Group, Vall d'Hebron Institute of Oncology, University Hospital Vall d'Hebron, Barcelona, Spain.
Tsun L ChanHong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong.
Annie T W ChuHong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong.
Wendy K ChungDepartments of Pediatrics and Medicine, Columbia University, New York, New York.
Kathleen B M ClaesCentre for Medical Genetics, Ghent University, Ghent, Belgium.ORCID 0000-0003-0841-7372
Gemo Study CollaboratorsService de Génétique, Institut Curie, Paris, France.
Embrace CollaboratorsCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Jackie CookSheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom.
Laura CortesiDepartment of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Giuseppe DamanteDepartment of Medical and Biological Sciences, University of Udine, Udine, Italy.
Esther DarderGenetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain.ORCID 0000-0002-7764-1397
Rosemarie DavidsonDepartment of Clinical Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom.
Miguel de la HoyaMedical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Lara Della PuppaDivision of Functional Onco-genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.
Joe DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-4591-1214
Orland DíezOncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Barcelona, Spain.
Yuan Chun DingDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California.
Nina DitschDepartment of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany.
Susan M DomchekDepartment of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Alan DonaldsonClinical Genetics Department, St Michael's Hospital, Bristol, United Kingdom.
Bernd DworniczakInstitute of Human Genetics, University of Münster, Münster, Germany.ORCID 0000-0003-4981-7903
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Diana M EcclesCancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Rosalind A EelesOncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.ORCID 0000-0002-3698-6241
Hans EhrencronaDepartment of Clinical Genetics, Lund University Hospital, Lund, Sweden.ORCID 0000-0002-5589-3622
Bent EjlertsenDepartment of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.ORCID 0000-0001-8761-714X
Christoph EngelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
D Gareth EvansDivision of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health and Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.ORCID 0000-0002-8482-5784
Laurence FaivreUnité d'oncogénétique, Centre de Lutte Contre le Cancer, Centre Georges-François Leclerc, Dijon, France.
Ulrike FaustInstitute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
Lídia FeliubadalóMolecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain.
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Florentia FostiraMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Athens, Greece.
George FountzilasSecond Department of Medical Oncology, EUROMEDICA General Clinic of Thessaloniki, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
Debra FrostCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Vanesa García-BarberánMedical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Pilar GarreMedical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.ORCID 0000-0001-8285-4138
Marion Gauthier-VillarsService de Génétique, Institut Curie, Paris, France.
Lajos GécziDepartment of Chemotherapy, National Institute of Oncology, Budapest, Hungary.
Andrea GehrigCentre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University of Würzburg, Würzburg, Germany.
Anne-Marie GerdesDepartment of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark.
Paul GestaService Régional Oncogénétique Poitou-Charentes, CH Niort, Niort, France.
Giuseppe GianniniDepartment of Molecular Medicine, University La Sapienza, Rome, Italy.
Gord GlendonFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Andrew K GodwinDepartment of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, Kansas.
David E GoldgarDepartment of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.
Mark H GreeneClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.ORCID 0000-0003-1852-9239
Angelica M Gutierrez-BarreraDepartment of Breast Medical Oncology and Clinical Genetics Program, University of Texas MD Anderson Cancer Center, Houston, Texas.
Eric HahnenCenter for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jan HaukeCenter for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
Natalie HeroldCenter for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
Frans B L HogervorstFamily Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Ellen HonischDepartment of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Peter J HulickCenter for Medical Genetics, NorthShore University HealthSystem, Evanston, Illinois.ORCID 0000-0001-8397-4078
KConFab InvestigatorsPeter MacCallum Cancer Center, Melbourne, Victoria, Australia.
Hebon InvestigatorsThe Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Coordinating center: The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Louise IzattClinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Agnes JagerDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.ORCID 0000-0002-7713-1450
Paul JamesSir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-4361-4657
Ramunas JanaviciusHematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania.
Uffe Birk JensenDepartment of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
Thomas Dyrso JensenDepartment of Clinical Genetics, Vejle Hospital, Vejle, Denmark.
Oskar Th JohannssonDepartment of Oncology, Landspitali University Hospital, Reykjavik, Iceland.
Esther M JohnDivision of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California.ORCID 0000-0003-3259-8003
Vijai JosephClinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York.ORCID 0000-0002-7933-151X
Eunyoung KangDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
Karin KastDepartment of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany.
Johanna I KiiskiDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Sung-Won KimDepartment of Surgery, Daerim Saint Mary's Hospital, Seoul, Korea.ORCID 0000-0002-1413-2800
Zisun KimDepartment of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.ORCID 0000-0002-1413-2800
Kwang-Pil KoDepartment of Preventive Medicine, Gacheon University College of Medicine, Incheon, Republic of Korea.
Irene KonstantopoulouMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Athens, Greece.ORCID 0000-0002-0470-0309
Gero KramerDepartment of Urology, Medical University of Vienna, Vienna, Austria.
Lotte KroghDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Torben A KruseDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Ava KwongHong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong.
Mirjam LarsenCenter for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
Christine LassetUnité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.
Charlotte LautrupDepartment of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark.
Conxi LazaroMolecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain.
Jihyoun LeeDepartment of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, Korea.
Jong Won LeeDepartment of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, Korea.
Min Hyuk LeeDepartment of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, Korea.
Johannes LemkeInstitute of Human Genetics, University Hospital Leipzig, Leipzig, Germany.
Fabienne LesueurService de Génétique, Institut Curie, Paris, France.ORCID 0000-0001-7404-4549
Annelie LiljegrenDepartment of Oncology, Karolinska Institutet, Stockholm, Sweden.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Patricia LlovetMedical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Adria Lopez-FernándezHigh Risk and Cancer Prevention Group, Vall d'Hebron Institute of Oncology, University Hospital Vall d'Hebron, Barcelona, Spain.
Irene Lopez-PerolioMedical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Victor LorcaMedical Oncology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Jennifer T LoudClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Edmond S K MaHong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong.
Phuong L MaiMagee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Siranoush ManoukianUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Veronique MariDépartement d'Hématologie-Oncologie Médicale, Centre Antoine Lacassagne, Nice, France.
Lynn MartinInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
Laura MatricardiImmunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.ORCID 0000-0002-0241-1810
Noura MebiroukService de Génétique, Institut Curie, Paris, France.
Veronica MediciDepartment of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy.
Hanne E J Meijers-HeijboerDepartment of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands.
Alfons MeindlDepartment of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany.
Arjen R MensenkampDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
Clare MillerDepartment of Clinical Genetics, Alder Hey Hospital, Liverpool, United Kingdom.
Denise Molina GomesService de Biologie de la Reproduction, Cytogénétique et Génétique Médicale, CHI Poissy - Saint Germain, Poissy, France.ORCID 0000-0002-2836-9008
Marco MontagnaImmunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Thea M MooijDepartment of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Lidia MoserleImmunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Emmanuelle Mouret-FourmeService de Génétique, Institut Curie, Paris, France.
Anna Marie MulliganDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Katherine L NathansonDepartment of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Marie NavratilovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-0916-2976
Dieter NiederacherCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Finn C Cilius NielsenCenter for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Liene Nikitina-ZakeLatvian Biomedical Research and Study Centre, Riga, Latvia.
Kenneth OffitDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
Edith OlahDepartment of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics, The University of Chicago, Chicago, Illinois.ORCID 0000-0002-9936-1599
Kai-Ren OngWest Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, United Kingdom.
Ana OsorioHuman Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Claus-Eric OttInstitute for Medical Genetics and Human Genetics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.ORCID 0000-0002-5558-2437
Sue K ParkDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.ORCID 0000-0001-5002-9707
Michael T ParsonsDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-3242-8477
Inge Sokilde PedersenSection of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
Bernard PeisselUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Ana PeixotoDepartment of Genetics, Portuguese Oncology Institute, Porto, Portugal.
Pedro Pérez-SeguraDepartment of Oncology, Hospital Clinico San Carlos, IdISSC, Madrid, Spain.
Paolo PeterlongoGenome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.ORCID 0000-0001-6951-6855
Annabeth Høgh PetersenDepartment of Clinical Genetics, Vejle Hospital, Vejle, Denmark.ORCID 0000-0002-4503-6942
Mary E PorteousSouth East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, United Kingdom.
Miguel Angel PujanaTranslational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain.ORCID 0000-0003-3222-4044
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, in Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy.
Juliane RamserDivision of Gynaecology and Obstetrics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.
Johanna RantalaClinical Genetics, Karolinska Institutet, Stockholm, Sweden.
Muhammad U RashidMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kerstin RhiemCenter for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
Piera RizzoloDepartment of Molecular Medicine, University La Sapienza, Rome, Italy.
Mark E RobsonClinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
Matti A RookusDepartment of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Caroline M RossingCenter for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Kathryn J RuddyDepartment of Oncology, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0001-6298-332X
Catarina SantosDepartment of Genetics, Portuguese Oncology Institute, Porto, Portugal.
Claire SauleService de Génétique, Institut Curie, Paris, France.
Rosa ScarpittaSection of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy.ORCID 0000-0001-7590-3827
Rita K SchmutzlerCenter for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Hélène SchusterUnité d'Oncogénétique, Centre de Lutte Contre le Cancer Paul Strauss, Strasbourg, France.
Leigha SenterClinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
Caroline M SeynaeveDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Payal D ShahDepartment of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-5874-3390
Priyanka SharmaDepartment of Internal Medicine, Division of Oncology, University of Kansas Medical Center, Westwood, Kansas.
Vivian Y ShinDepartment of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Valentina SilvestriDepartment of Molecular Medicine, University La Sapienza, Rome, Italy.ORCID 0000-0003-0712-9379
Jacques SimardGenomics Center, Centre Hospitalier Universitaire de Québec - Université Laval, Research Centre, Québec City, Québec, Canada.
Christian F SingerDept of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Anne-Bine SkytteDepartment of Clinical Genetics, Vejle Hospital, Vejle, Denmark.
Katie SnapeMedical Genetics Unit, St George's, University of London, London, United Kingdom.
Angela R SolanoINBIOMED, Faculty of Medicine/CONICET and CEMIC, Department of Clinical Chemistry, Medical Direction, University of Buenos Aires, Buenos Aires, Argentina.
Penny SoucyDepartment of Internal Medicine, Division of Oncology, University of Kansas Medical Center, Westwood, Kansas.
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-6313-9005
Amanda B SpurdleDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.ORCID 0000-0003-1337-7897
Linda SteeleDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California.
Doris SteinemannInstitute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.
Dominique Stoppa-LyonnetService de Génétique, Institut Curie, Paris, France.ORCID 0000-0002-5438-8309
Agostina StradellaGenetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain.
Lone SundeDepartment of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-8479-165X
Christian SutterInstitute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Yen Y TanDepartment of OB/GYN, Medical University of Vienna, Vienna, Austria.
Manuel R TeixeiraDepartment of Genetics, Portuguese Oncology Institute, Porto, Portugal.ORCID 0000-0002-4896-5982
Soo Hwang TeoCancer Research Malaysia, Subang Jaya, Selangor, Malaysia.ORCID 0000-0002-0444-590X
Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Maria Grazia TibilettiUO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, Italy.
Marc TischkowitzProgram in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, Quebec, Canada.
Silvia TognazzoImmunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Amanda E TolandDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio.
Stefania TommasiIstituto Nazionale Tumori 'Giovanni Paolo II, Bari, Italy.ORCID 0000-0002-2157-2978
Diana TorresMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Angela TossDepartment of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0002-1854-6701
Alison H TrainerParkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.
Nadine TungDepartment of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Christi J van AsperenDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Frederieke H van der BaanDepartment of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Lizet E van der KolkFamily Cancer Clinic, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Rob B van der LuijtDepartment of Medical Genetics, University Medical Center, Utrecht, the Netherlands.ORCID 0000-0002-0018-1089
Liselotte P van HestClinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Liliana VarescoUnit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) AOU San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
Raymonda Varon-MateevaInstitute for Medical Genetics and Human Genetics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Alessandra VielDivision of Functional Onco-genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy.
Jeroen VierstraeteCentre for Medical Genetics, Ghent University, Ghent, Belgium.ORCID 0000-0001-7909-6620
Roberta VillaUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Anna von WachenfeldtDepartment of Oncology, Karolinska Institutet, Stockholm, Sweden.
Philipp WagnerDepartment of Women's Health, Tubingen University Hospital, Tubingen, Germany.
Shan Wang-GohrkeDepartment of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
Barbara WappenschmidtCenter for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Jeffrey N WeitzelClinical Cancer Genetics, City of Hope, Duarte, California.
Greet WiemeCentre for Medical Genetics, Ghent University, Ghent, Belgium.ORCID 0000-0003-2718-5300
Siddhartha YadavDepartment of Oncology, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0003-4630-9903
Drakoulis YannoukakosMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Athens, Greece.
Sook-Yee YoonCancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Selangor, Malaysia.
Cristina ZanzotteraUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Kristin K ZornMagee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Anthony V D'AmicoDepartment of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts.
Matthew L FreedmanDana-Farber Cancer Institute. Boston, Massachusetts.
Mark M PomerantzDana-Farber Cancer Institute. Boston, Massachusetts.
Georgia Chenevix-TrenchDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-9223-3116
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California.
Laura OttiniDepartment of Molecular Medicine, University La Sapienza, Rome, Italy.
Henriette Roed NielsenDepartment of Clinical Genetics, Odense University Hospital, Odense, Denmark.
Timothy R RebbeckHarvard T.H. Chan School of Public Health, Boston, Massachusetts. Timothy_Rebbeck@dfci.harvard.edu.
Cancer Research UK Cambridge Center · GBUniversity of Cologne · DEInstituto de Investigación Sanitaria del Hospital Clínico San Carlos · ESFondazione IRCCS Istituto Nazionale dei Tumori · ITInstitut Curie · FRIstituto Oncologico Veneto · ITBreast Cancer Research Foundation · USCity of Hope · USCopenhagen University Hospital · DKHebron University · PSInstitut d'Investigació Biomédica de Bellvitge · ESKarolinska Institutet · SEOdense University Hospital · DKPeter MacCallum Cancer Centre · AUReykjavík University · ISSapienza University of Rome · ITUniversity of Pennsylvania · USDana-Farber Cancer Institute · USEuropean Institute of Oncology · ITGerman Cancer Research Center · DE

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
Statistics CoreU10CA180822 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mei-Yin C Polley · 2014 to 2026
$146.4M
GYNECOLOGIC ONCOLOGY GROUP HEADQUARTERSU10CA027469 · NCI · GYNECOLOGIC ONCOLOGY GROUP · PI DISAIA, PHILIP J. · 1985 to 2013
$132.6M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Clinical Genetic Studies of Familial and Hereditary Cancer SyndromesZIACP010144 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$111.8M
Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI STEPHEN W BYERS · 1990 to 2026
$71.5M
GYNECOLOGIC ONCOLOGY GROUP STATISTICAL OFFICEU10CA037517 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI BLESSING, JOHN A · 1985 to 2013
$67.4M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9M
Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NICOLE L NOLLEN · 2012 to 2026
$40.1M
Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Steven Allan Soper, Alan S Yu · 2019 to 2026
$21.5M
Cancer Research UK 10118Cancer Research UK 20861Cancer Research UK 23382Cancer Research UK C12292/A11174Cancer Research UK C12292/A20861Cancer Research UK C1281/A12014Cancer Research UK C1287/A 10710Cancer Research UK C5047/A10692Cancer Research UK C5047/A15007Cancer Research UK C5047/A8384Cancer Research UK C5047/A8385FCCCCancer Research UK C8197/A16565NCATS NIH HHS UL1 TR000124NCI NIH HHS N02 CP011019NCI NIH HHS N02 CP065504NCI NIH HHS P20 CA233255NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA051008NCI NIH HHS P30 CA168524NCI NIH HHS P50 CA105641NCI NIH HHS P50 CA116201NCI NIH HHS P50 CA125183NCI NIH HHS R01 CA116167NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA142996NCI NIH HHS R01 CA149429NCI NIH HHS R01 CA176785NCI NIH HHS R01 CA192393NCI NIH HHS R01 CA214545NCI NIH HHS R03 CA130065NCI NIH HHS R25 CA112486NCI NIH HHS RC4 CA153828NCI NIH HHS T32 CA009001NCI NIH HHS U01 CA116167NCI NIH HHS U01 CA161032NCI NIH HHS U10 CA027469NCI NIH HHS U10 CA037517NCI NIH HHS U10 CA180822NCI NIH HHS U10 CA180868NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA164920NIGMS NIH HHS P20 GM130423
6 · The paper itself

Abstract

Pathogenic sequence variants (PSV) in

Indexed as

Genetic Predisposition to DiseaseMutationAdolescentAdultAgedAged, 80 and overBRCA1 ProteinBRCA2 ProteinGenetic Association StudiesGenomicsHeterozygoteHumansMaleMiddle AgedPrognosisProstatic NeoplasmsBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, human

Identifiers

PMID31723001
PMCPMC7553241
OpenAlexW2979840360

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.