Evidence map›Paper›PMID 31722976›Full record

ArticleJournal of cell science2019

Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish.

Taylor J Schoen, Emily E Rosowski, Benjamin P Knox, David Bennin, Nancy P Keller, Anna Huttenlocher

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

  1. Current issues in molecular biology · 2026
    Article
  2. Article
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  4. DHRS7 Integrates NADPbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
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  13. bioRxiv : the preprint server for biology · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. The Pathogenesis ofPolish journal of microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Taylor J SchoenDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Emily E RosowskiDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-6761-1098
Benjamin P KnoxDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.
David BenninDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-4386-9473
Anna HuttenlocherDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA huttenlocher@wisc.edu.ORCID 0000-0001-7940-6254
University of Wisconsin–Madison · US

Funding

Biology of Aging and Age-Related Diseases Training GrantT32AG000213 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Rozalyn M. Anderson, Sanjay Asthana · 1991 to 2026
$9.9M
Cell migration and wound repairR35GM118027 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher · 2016 to 2026
$7.5M
Mechanisms of an Aspergillus fumigatus virulence mutantR01AI065728 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KELLER, NANCY P · 2006 to 2017
$3.6M
NIAID NIH HHS R01 AI065728NIA NIH HHS T32 AG000213NIGMS NIH HHS R35 GM118027
6 · The paper itself

Abstract

Neutrophils are primary phagocytes of the innate immune system that generate reactive oxygen species (ROS) and mediate host defense. Deficient phagocyte NADPH oxidase (PHOX) function leads to chronic granulomatous disease (CGD) that is characterized by invasive infections, including those by the generally non-pathogenic fungus

Indexed as

AnimalsAspergillosisAspergillus nidulansGranulomatous Disease, ChronicInflammationModels, AnimalNADPH OxidasesNeutrophilsReactive Oxygen SpeciesZebrafishNADPH OxidasesReactive Oxygen SpeciesAspergillusChronic granulomatous diseaseNeutrophilsPhagocyte oxidase/reactive oxygen speciesZebrafish

Identifiers

PMID31722976
PMCPMC7055366
OpenAlexW2984202313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.